Investigator Argus X-12试剂盒在华东汉族人群中的法医学应用评估

目的 调查Investigator Argus X-12试剂盒中所包含的12个X-STR基因座在华东汉族人群中的遗传学数据,考察其法医学应用价值.方法 应用Investigator Argus X-12试剂盒对华东地区309名汉族无关个体进行X-STR基因座分型检测,统计分析12个X-STR基因座的频率数据、群体遗传学...

Forensic application of investigator Argus X-12 kit in Han population from East China

Objective To investigate the genetic data of the 12 X-STR included in Investigator Argus X-12 kit and to evaluate the forensic application in Han population from East China.Methods By detecting 309 unrelated individuals with Investigator Argus X-12 kit,allele frequencies,population genetics parameters and the information of linkage disequilibrium of the 12 X-STR were analyzed by statistics and were compared with available data of other Han populations from different regions.Results No deviations from Hardy-Weinberg equilibrium were detected.Except loci of DXS10103 and DXS10101 linked closely,all other loci were independent while HET exceed 0.5 and PIC all above 0.4.Distributions of allele frequencies of all loci were not significant statistically except for locus of DXS10146 in Han population from Guangdong.Conclusion Loci of Investigator Argus X-12 kit were highly polymorphic in Han population from East China,which is suitable for forensic application in paternity testing and individual identification.