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傅里叶显微红外光谱成像技术研究进展及其法医学应用
引用本文:Huang P,Li SY,Li ZD,Shao Y,Li L,Chen YY,Chen YJ. 傅里叶显微红外光谱成像技术研究进展及其法医学应用[J]. 法医学杂志, 2011, 27(6): 447-450. DOI: 10.3969/j.issn.1004-5619.2011.06.013
作者姓名:Huang P  Li SY  Li ZD  Shao Y  Li L  Chen YY  Chen YJ
作者单位:1. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海,200063
2. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海200063;复旦大学 上海医学院法医学系,上海200032
3. 司法部司法鉴定科学技术研究所 上海市法医学重点实验室,上海200063;苏州大学 医学部法医学系,江苏苏州215123
基金项目:国家自然科学基金,上海市自然科学基金,上海市法医学重点实验室资助项目
摘    要:傅里叶显微红外光谱成像技术可收集微小物体的红外光谱信息,针对组织切片和细胞进行扫描,记录选择区域像素位点的红外光谱信息,并通过计算机软件构建出组织和细胞中光谱吸收峰的二维和三维光谱映射图像.由于红外光谱对生物大分子的敏感性,通过该技术可以有效分析组织和细胞的生化构成、分子分布、代谢变化.本文阐述了傅里叶显微红外光谱成像...

关 键 词:法医病理学  谱学,傅里叶变换红外  综述[文献类型]  显微成像

Research advancement of FTIR-MSP mapping and application value in forensic science
Huang Ping,Li Shi-Ying,Li Zheng-Dong,Shao Yu,Li Li,Chen Yuan-Yuan,Chen Yi-Jiu. Research advancement of FTIR-MSP mapping and application value in forensic science[J]. Journal of Forensic Medicine, 2011, 27(6): 447-450. DOI: 10.3969/j.issn.1004-5619.2011.06.013
Authors:Huang Ping  Li Shi-Ying  Li Zheng-Dong  Shao Yu  Li Li  Chen Yuan-Yuan  Chen Yi-Jiu
Affiliation:Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, Shanghai 200063, PR China. huangpingifs@gmail.com
Abstract:Fourier transformation infrared microspectroscopy (FTIR-MSP) mapping technique can collect the infrared information from micro-samples and scan the tissue slides and cells. The infrared spectral information of pixels from the collected regions is recorded and infrared spectral maps are constructed by computer software. The 2D and 3D mapping images are reflected based on the distributions of absorbance bands. The biochemical compositions, molecular distribution, metabolic changes of tissues and cells are analyzed by the technique due to infrared spectroscopy being sensitive to biomolecules. The article reviews the recent research of FTIR-MSP mapping and explores the future potential value in forensic science practice.
Keywords:forensic pathology  spectroscopy  Fourier transform infrared  review[publication type]  microscopic mapping
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