| 眼外伤后GAP-43的时序性表达及法医学意义 |
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| 引用本文： | 倪收收,刘子龙,董娟,赵小红. 眼外伤后GAP-43的时序性表达及法医学意义[J]. 中国法医学杂志, 2014, 0(3): 240-243 |
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| 作者姓名： | 倪收收 刘子龙 董娟 赵小红 |
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| 作者单位： | 华中科技大学同济医学院法医学系; |
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| 基金项目： | 湖北省自然科学基金资助项目(2011CDB359) |
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| 摘 要： | 生长相关蛋白（GAP-43）是与神经发育、轴突再生、突触重建密切相关的一种快速转运胞膜磷酸蛋白,被认为是神经发育和再生的内在决定因子之一,在多种神经损伤过程中常可检测到GAP-43表达上调。本文综述眼外伤后GAP-43在视觉系统中的表达规律,并初步探讨其法医学意义,希望能为视神经损伤的法医学鉴定提供参考和借鉴。
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| 关 键 词： | 法医临床学 生长相关蛋白 时序性表达 视神经损伤 |
The sequential expression of GAP-43 after eye traumas and its significance of forensic medicine |
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| Ni Shoushou,Liu Zilong,Dong Juan,Zhao Xiaohong. The sequential expression of GAP-43 after eye traumas and its significance of forensic medicine[J]. Chinese Journal of Forensic Medicine, 2014, 0(3): 240-243 |
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| Authors: | Ni Shoushou Liu Zilong Dong Juan Zhao Xiaohong |
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| Affiliation: | (Department of Forensic Medicine, Tong]i Medical College of Huazhong University of Science and Technology, Wuhan 430030, China) |
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| Abstract: | Growth associated protein （GAP-43） is a kind of rapid transit cell membrane phosphateproteins which is closely related to neural development, axon regeneration and synaptic reconstruction. It is considered to be one of the internal decision factors in the procession of neural development and regeneration. The up-regulation of GAP-43 has been detected in a variety of neurological damages. In conclusion, we summarized the expression of GAP-43 in the visual system after ocular trauma and made a preliminary discussion on its significance of forensic medicine. Last but not least, we are expected to provide references on optic nerve injury in forensic assessment. |
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| Keywords: | forensic clinical medicine growth associated protein sequential expression optic nerve injury |
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