根据S—100蛋白阳性胶质细胞的变化判断脑挫伤时间的实验研究

本文米用免疫组织化学ＡＢＣ法，观察了２４只大白鼠脑挫伤不同时间的胶质细胞特异性标志物Ｓ－１００蛋白的变化。结果表明，挫伤２天后Ｓ—１００阳性胶质细胞的胞体开始增大，突起不明显，随着脑挫伤时间的延长，胞体增大，突起明显的Ｓ—１００阳性胶质细胞数量明显增加，到第五天时达高峰，在脑挫伤的周围区均为胞林大、突起明显的Ｓ—１００阳性细胞，此结果表明Ｓ－１００蛋白的变化可用于挫伤后时间的判断。

Experimental Study on Time Estimation of Brian Contusion through S-100 Protein Changes of Positive Glia

S-100 protein positive glia of 24 contused rats' beam c was observed at different intervals by immunothistochemical ABC method. The results showed that 2 days aftet contusion S-100 protein positive glia was enlarged with no distinct process. With longer duration of the cerebral contusion, the glia was enlarged and increased markedly and peaked at 5 days. The S-100 protein positive enlarged glia were distributed in periphery of contusive area. It is concluded that the S-100 protein can be used to estimate the time of brain contusion.