Near‐fatal Intoxication with the “New” Synthetic Opioid U‐47700: The First Reported Case in the Czech Republic |
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| Authors: | Monika Židková Ph.D. Rachel Horsley Ph.D. Ondřej Hloch M.D. Tomáš Hložek M.Sc. |
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| Affiliation: | 1. Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 121 08 Prague, Czech Republic;2. National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic;3. Department of Internal Medicine, Second Faculty of Medicine, Charles University, V úvalu 84, 150 06 Prague, Czech Republic;4. Department of Analytical Chemistry, Faculty of Science, Charles University, Albertov 6, 128 43 Prague, Czech RepublicCorresponding author: Tomá? Hlo?ek, M.Sc. E‐mail: |
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| Abstract: | Recreational use of the potent synthetic opioid 3,4‐ dichloro‐N‐(2‐(dimethylamino)cyclohexyl)‐N‐methylbenzamide (U‐47700) is rising, accompanied by increasingly frequent cases of serious intoxication. This article reports a case of near‐fatal U‐47700 intoxication. A man was found unconscious (with drug powder residues). After 40 h in hospital (including 12 h of supported ventilation), he recovered and was discharged. Liquid chromatography/high‐resolution mass spectrometry (LC/HRMS) or gas chromatography/mass spectrometry (GC/MS) were used to detect and quantify substances in powders, serum and urine. Powders contained U‐47700 and two synthetic cannabinoids. Serum and urine were positive for U‐47700 (351.0 ng/mL), citalopram (
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| Keywords: | forensic science forensic toxicology U47700 synthetic opioid 3,4‐ dichloro‐N‐(2‐(dimethylamino)cyclohexyl)‐N‐methylbenzamide clonazolam novel benzodiazepine novel psychoactive substance |
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