Identification and quantitation of 3,4-methylenedioxy-N-methylamphetamine (MDMA,ecstasy) in human urine by 1H NMR spectroscopy. Application to five cases of intoxication |
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Authors: | Jonathan Liu John Decatur Gloria Proni Elise Champeil |
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Affiliation: | 1. Department of Science, John Jay College of Criminal Justice, City University of New York, 445 west 59th Street, New York, NY, 10019, United States;2. Department of Chemistry, Columbia University, 3000 Broadway, New York, NY, 10027, United States |
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Abstract: | Identification of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in five cases of intoxication using nuclear magnetic resonance (NMR) spectroscopy of human urine is reported. A new water suppression technique PURGE (Presaturation Utilizing Relaxation Gradients and Echoes) was used. A calibration curve was obtained using spiked samples. The method gave a linear response (correlation coefficient of 0.992) over the range 0.01–1 mg/mL. Subsequently, quantitation of the amount of MDMA present in the samples was performed. The benefit and reliability of NMR investigations of human urine for cases of intoxication with MDMA are discussed. |
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