Chloroquine distribution in postmortem cases |
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| Authors: | J J Kuhlman R W Mayes B Levine R Jones G N Wagner M L Smith |
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| Affiliation: | Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC. |
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| Abstract: | Chloroquine concentrations in blood and tissues were examined in overdose and non-overdose cases to determine appropriate ranges for interpretation. Twenty-nine literature overdose cases and 8 non-overdose literature cases were compared with this laboratory's findings. The results indicate significant postmortem redistribution of chloroquine. Combining this laboratory's results and the literature results indicates that using a liver concentration of 150 mg/kg as a cutoff between overdose and non-overdose concentrations properly identified 30 of the 34 published cases containing liver chloroquine and 19 of the 20 presented cases. |
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