怀疑原发性脑干损伤早期死亡脑干纤维联结蛋白的免疫组化研究

在本研究的１３个案例中，怀疑原发性脑干伤死亡的５例，明确死因的８例，其中严重闭合性颅脑损伤２例；缢死１例，失血性休克１例，电击２例，海洛因中毒２例。用ＬＳＡＢ法对１３例脑干的中脑、脑桥、延髓各部ＦＮ进行检测。结果显示５例怀疑为原发性脑干伤、２例严重颅脑损伤、２例海洛因中毒死者的脑千部位的神经元内均可见ＦＮ的异常沉积，其它各例未见ＦＮ的异常沉积。结果表明；ＬＳＡＢ－ＦＮ法是诊断原发性脑干伤早期死亡灵敏但非特异的形态学指标。

Brain-Stem Fibronectin Studies Immunohistochemically in Early Dying Cases of Suspected Primary Brain-Stem Injury

In the thirteen cases studied below. five are suspected primary brain-stem injury,the other eight are clear in the cause of death,including severe closed craniocerebral injury(2 cases),hanging(1 case),hemorrhagic shock(1 case),death from electricity(2 cases) and heroin poisoning(2 cases).FN in brain-stem (midbrain pons and medullary bulb) is detected in some brain-stem neurons in all cases of the suspected primary brain-stem injury, severe craniocerebral injury and beroin poisoning.Thus LSAB-FN method is not specific but very sensitive morphologic parameter of primary brain-stem injury