| 儿茶酚胺致心肌损伤的实验病理研究 |
| |
| 引用本文： | 姚季生,应爱娣,颜召文,佘伟亮,韩玉升. 儿茶酚胺致心肌损伤的实验病理研究[J]. 中国法医学杂志, 1994, 0(4) |
| |
| 作者姓名： | 姚季生 应爱娣 颜召文 佘伟亮 韩玉升 |
| |
| 作者单位： | 上海第二医科大学法医学教研室!200025(姚季生，应爱娣，颜召文，佘伟亮)，上海第二医科大学生物物理教研室(韩玉升) |
| |
| 摘 要： | 大鼠尾静脉滴去甲肾上腺素（20μg／kg／min）后，分别于即刻、7天、30～90天杀死取材，用病理组织学、肌红蛋白免疫组化染色及透射电镜观察心肌损伤。结果：早期可见心肌多灶性坏死、肌红蛋白缺染、肌原纤维断裂溶解，似冠状动脉无阻塞性心肌梗死；中后期可见心肌灶性萎缩及疤痕形成、成纤维细胞增生活跃、新生胶元原纤维伸入坏死心肌内，类似早期心肌病图象。
|
| 关 键 词： | 心源性急死 去甲肾上腺素 肌红蛋白免疫组化 心肌超微结构 心肌梗死 |
EXPERIMENTAL PATHOLOGICAL STUDY OF MYOCARDIAL DAMAGE INDUCED BY CATECHOLAMINE |
| |
| Yao Jisheng,Ying Aidi,Yan Zhaowen,She Weiliang. EXPERIMENTAL PATHOLOGICAL STUDY OF MYOCARDIAL DAMAGE INDUCED BY CATECHOLAMINE[J]. Chinese Journal of Forensic Medicine, 1994, 0(4) |
| |
| Authors: | Yao Jisheng Ying Aidi Yan Zhaowen She Weiliang |
| |
| Affiliation: | Yao Jisheng,Ying Aidi,Yan Zhaowen,She WeiliangDepartment of Forensic Medicthe,Shanghai Second Medical Universiry 200025 |
| |
| Abstract: | The experimental myocardial damages were induced in Wistar rats by noradrenaline infusion (20ug/kg body wt/minute)for a period of 90 minutes daily for three consecutive days. The animals weresacrificed few minutes (acute phase), 7 days(subacute phase),and 30~90 days (chronic phase)afterinfusion. Specimens of myocardium were examined by histopathological, immunohistochemical and ultrastructural methods. Multiple focal necrosis, deficient of myoglobin in myocytes, myofibrillar fragmentation and dissolution were observed in the acute phase. The mdrphofogical feature simulated themyocardial infarctinn without coronary occlusion. Focal myocardial atrophy, scar f0rmation of myocardium, proliferation of fibroblasts and infiltraiton of the neo-colleagenous fibrils in necrotic myocytes were observed in the subacute and chronic phase. This feacture simulated the early cardiomyopathy. |
| |
| Keywords: | Sudden cardiac death Noradrenaline Immunohistochemistry of myoglobin Myocardial infarction Utrustructure of mgocytes |
| 本文献已被 CNKI 等数据库收录！ |
|
