| 急性心肌缺血猝死心肌中血红素加氧酶-1的表达 |
| |
| 引用本文： | 彭雪,靳占峰,邵洪江,高铁磊. 急性心肌缺血猝死心肌中血红素加氧酶-1的表达[J]. 中国法医学杂志, 2010, 25(3): 162-165 |
| |
| 作者姓名： | 彭雪 靳占峰 邵洪江 高铁磊 |
| |
| 作者单位： | 哈尔滨医科大学法医学教研室,黑龙江,哈尔滨,150081 |
| |
| 基金项目： | 黑龙江省博士后科研启动基金 |
| |
| 摘 要： | 目的观察血红素加氧酶-1（HO-1）在急性心肌缺血猝死心肌细胞胞浆中的表达情况。方法应用免疫组织化学技术（SP法）,对27例可疑早期心肌缺血猝死（早期梗死组）、10例心肌梗死猝死（心肌梗死组）、11例冠心病非心性猝死（对照组1）以及10例正常心肌（对照组2）中HO-1的表达进行观察分析。结果早期梗死组与心肌梗死组在心肌细胞胞浆中HO-1均呈强阳性表达,对照组1和对照组2心肌细胞胞浆中HO-1弱阳性表达或无表达。早期梗死组和心肌梗死组与对照组1和对照组2之间心肌细胞内HO-1表达的差异有显著性意义（P（0.01）;镜下各组心肌细胞胞浆内HO-1表达的阳性面积率及平均光密度差别明显。结论 HO-1可以作为急性心肌缺血所致心性猝死的一个诊断指标。
|
| 关 键 词： | 法医病理学 免疫组织化学 血红素加氧酶-1 心肌梗死 |
An immunohistochemical study on heme oxygenase-1 in cases of sudden deaths from acute myocardial ischemia |
| |
| PENG Xue,JIN Zhanfeng,SHAO Hongjiang,GAO Tielei. An immunohistochemical study on heme oxygenase-1 in cases of sudden deaths from acute myocardial ischemia[J]. Chinese Journal of Forensic Medicine, 2010, 25(3): 162-165 |
| |
| Authors: | PENG Xue JIN Zhanfeng SHAO Hongjiang GAO Tielei |
| |
| Affiliation: | (PENG Xue,JIN Zhanfeng,SHAO Hongjiang,GAO Tielei/Haerbin Medical University School of Forensic Medicine,Haerbin 150081,China) |
| |
| Abstract: | Objective To investigate the changes of heme oxygenase-1(HO-1)in cases of sudden deaths from acute myocardial ischemia. Methods HO-1 was detected by immunohistochemical SP method in 27 hearts from cases with early myocardial ischemia and 10 hearts from cases with myocardial infarction. 11 hearts from cases who had coronary heart disease but not sudden cardiac death as control 1 and 10 normal hearts were used as control 2. Results Weak or negative HO-1 immunostaining was observed in all the control 1 or 2 my... |
| |
| Keywords: | forensic pathology immunohistochemistry HO-1 myocardial infarction |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
