代谢组学技术在法医病理学中的研究进展

代谢组学(metabolomics)是在后基因组学时代兴起的一门跨领域学科,其主要目标是定量研究生命体对外界刺激,病理生理变化,以及本身基因突变而产生的体内代谢物水平的多元动态反应。代谢组学在系统生物学、药物医学、临床医学等方面有着广泛的基础应用研究。在法医学方面,主要集中在法医毒理学研究,但随着技术方法的推广,可以预测其在法医病理学有着广阔的研究前景。本文概括了代谢组学的主要分析技术和方法,叙述了代谢组学技术在法医病理学中的研究现状,主要包括死亡时间和死亡原因,并对以后可能的应用领域进行总结和探讨,希望能为相关研究和应用提供参考。

Research Progress of Metabolomics in Forensic Pathology

Metabolomics is an interdisciplinary subject that rose in the post-genomic era,which focuses on quantitative study of the response of living organisms to outside stimulation and pathophysiological changes,as well as multiple dynamic response of the level of in vivo metabolites caused by genetic mutation.It is extensively used in basic research of system biology,materia medica,clinical medicine,etc.In the forensic field,metabolomics mainly focuses on forensic toxicology,but with the generalization of certain techniques,it’s foreseeable that metabolomics has a broad research prospect in forensic pathology.This article summarizes the major analysis techniques and methods of metabolomics,describes the research status of metabolomic techniques in the field of forensic pathology application research,including postmortem interval and death cause.Moreover,this article summarizes and discusses the potential applicable areas,in order to provide reference for relative research and application.