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The determination of clozapine in blood and urine by gas chromatography-mass spectrometry] |
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| Authors: | A B Melent'ev I V Kurochkina |
| Abstract: | A method for measuring closapine in the blood and urine by gas chromatography-mass spectrometry as a trifluoroacetic derivative is proposed. The threshold level for closapine detection is 25 ng/ml in the blood and 30 ng/ml in the urine. Calibration curves are linear in the range 0.025-5 mcg/ml for the blood and 0.03-50 mcg/ml for the urine. The method can be used in forensic chemical and clinical toxicological analysis. |
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