| 阿普唑仑在家兔体内的分布研究 |
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| 引用本文： | 贠克明,李贵明,王瑢. 阿普唑仑在家兔体内的分布研究[J]. 中国法医学杂志, 1996, 0(4) |
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| 作者姓名： | 贠克明 李贵明 王瑢 |
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| 作者单位： | 山西医科大学法医学系!太原，030001，山西医科大学法医学系!太原，030001，公安部管理干部学院山西分院!太原，030021 |
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| 摘 要： | 建立生物检材内阿普唑仑的薄层扫描定性定量检测方法，研究阿普唑仑在染毒家兔体内的分布情况。家兔按21mg/Kg剂量灌胃染毒后4h，其体内肝、脾、肾、肺、心、脑、血、胆汁和尿内阿普唑仑的浓度分别为19．6±6．1、3．3±0．5、3．5±0．3、0．4±0．1、0．4±0．1、1．6±1．8、4．0±1．3、20．4±8．5和8.6±2．4（ug／g或ug／ml）。阿普唑仑在染毒家兔体内的分布不均匀，血、胆汁和尿是阿普唑仑中毒死者毒物分析较好的检材。
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| 关 键 词： | 阿普唑仑 中毒 分布 薄层色谱 |
STUDY ON DISTRIBUTION OF ALPRAZOLAM IN EXPERIMENTAL POISONED RABBITS |
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| Yun Keming, Li Guiming. STUDY ON DISTRIBUTION OF ALPRAZOLAM IN EXPERIMENTAL POISONED RABBITS[J]. Chinese Journal of Forensic Medicine, 1996, 0(4) |
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| Authors: | Yun Keming Li Guiming |
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| Abstract: | A qualitative and quantitative analysis of alprazolam in biological samples by TLC scan is described in this paper. The distribution of alprazolam in poisoned rabbits was studied. It is showed that 4 hours after a dose of 21mg/kg, the concentration of the drug in liver, spleen, kidney; lungs, heart,brain, blood,bile and urine of poisoned rabbits were 19. 6 ± 6. 1, 3.31±0. 5, 3. 5± 0. 3, 0. 4± 0.1, 0. 4 ±0. 1, 1. 6 ± 1. 8, 4. 0 ± 1. 3, 20. 4 ± 8.0 and 8. 6 ± 2. 4ug/ml. Alprazolam is not well-distributed in poisoned rabbits. Blood, bile, urine and liver are better samples for analysis of alprazolam poisoning victim. |
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| Keywords: | Alprazolam poisoning TLC |
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