| microRNAs及其法医学应用前景 |
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| 引用本文： | 陈琦,易少华,黄代新. microRNAs及其法医学应用前景[J]. 中国法医学杂志, 2012, 27(3): 215-218 |
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| 作者姓名： | 陈琦 易少华 黄代新 |
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| 作者单位： | 华中科技大学同济医学院法医学系,湖北武汉,430030 |
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| 摘 要： | microRNAs(miRNAs)是一类内源性的非编码小分子RNA,平均长度约22nt,广泛存在于各种真核细胞中,并参与调节细胞生长发育、分化、凋亡、衰老、疾病及肿瘤的发生等众多重要生命活动。基于其生物学功能,miRNAs可能在法医学体液来源鉴定、个体年龄推断、同卵双生子甄别等方面具有广阔的应用前景。
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| 关 键 词： | 法医物证学 microRNAs 体液鉴定 年龄推断 同卵双生子甄别 |
microRNAs and their prospects for forensic applications |
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| Chen Qi , Yi Shaohua , Huang Daixin. microRNAs and their prospects for forensic applications[J]. Chinese Journal of Forensic Medicine, 2012, 27(3): 215-218 |
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| Authors: | Chen Qi Yi Shaohua Huang Daixin |
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| Affiliation: | /Faculty of Forensic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China) |
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| Abstract: | microRNAs(miRNAs) are a class of small,endogenous,non-protein-coding RNA molecules of approximately 22 nucleotides in length,and exist extensively in a variety of eukaryotic cells.miRNAs regulate gene expression and play fundamental roles in multiple biological processes,including cell differentiation,proliferation and apoptosis as well as aging and disease processes.Based on their biological characteristics,miRNAs have broad application prospects in the field of forensic science,such as forensic body fluid identification,individual age estimation and discrimination of monozygotic twins. |
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| Keywords: | forensic biological evidence microRNAs forensic body fluid identification age estimation discrimination of monozygotic twins |
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