| 大鼠急性早期心肌梗死细胞膜PNA受体表达 |
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| 引用本文： | 李朝晖,竞花兰,王芏伦,祝家镇. 大鼠急性早期心肌梗死细胞膜PNA受体表达[J]. 中国法医学杂志, 2000, 15(Z1): 23-24 |
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| 作者姓名： | 李朝晖 竞花兰 王芏伦 祝家镇 |
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| 作者单位： | 1. 中山医科大学法医学系,广州,510089
2. 广州药学院,广州,510000 |
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| 摘 要： | 探测急性心肌缺血早期细胞膜PNA受体的表达特点。应用免疫组化法(S-P法)对32只SD大鼠急性心肌缺血早期不同时间心肌细胞膜凝集素受体的表达进行研究。结果发现:心肌缺血15min时,心肌局部可出现PNA染色阳性,且随着缺血时间的延长,其阳性表达面积明显增加;缺血2h;其表达水平达到高峰,呈弥漫性染色阳性,明显高于对照组;2h后,心肌缺血区域PNA受体的表达开始出现下降趋势。实验结果稳定,敏感性强,可为心肌缺血早期诊断提供客观的依据。
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| 关 键 词： | 急性心肌缺血 花生凝集素 免疫组织化学 |
| 修稿时间： | 1999-11-01 |
Study on expression of the PNA receptor on the myocardial cell membrane of the early rat's myocardial infarction |
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| /LI Zhaohui,JING Hualan,WANG Dulun,et al.. Study on expression of the PNA receptor on the myocardial cell membrane of the early rat's myocardial infarction[J]. Chinese Journal of Forensic Medicine, 2000, 15(Z1): 23-24 |
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| Authors: | /LI Zhaohui JING Hualan WANG Dulun et al. |
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| Affiliation: | /LI Zhaohui,JING Hualan,WANG Dulun,et al. /Department of Forensic Medicine,Sun Yat-sen University of Medical Sciences Guangzhou 510089 |
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| Abstract: | In order to explore expression of the PNA receptor in early myocardial infarction, immunohistochemical technique was performed (S-P method). The expression of the PNA receptor occured in the early acute cardiac ischemic area induced experimentally by ligation of left coronary arteries of 32 SD rats. The following changes on myocardial cell membranes at the ischemical areas were found. Positive staining of PNA could be observed in ischemic area at 15min after ischemia, and it increased along with the prolongation of ischemic period. It became the strongest after is chemic 2h and then decreased. This may be of some value in forensic medicine practice. |
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| Keywords: | Early acute cardiac ischemic PNA Immunohistochemistry |
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