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Severe Hypokalemia due to Combination Use of Dexamethasone and Calcium Gluconate for Diabetics with Infection: A Case Report
Authors:HAN Shun-qi  QIN Zhi-qiang  DENG Kai-fei  ZHANG Jian-hua  LIU Ning-guo  ZOU Dong-hua  LI Zheng-dong  SHAO Yu  HUANG Ping  CHEN Yi-jiu
Abstract:The combination use of dexamethasone and calcium gluconate can be applied to hypersensitivity. Severe hypokalemia is a usual complication of dexamethasone and calcium gluconate therapy, which occurs frequently with therapeutic use. Fatal cases, accidental and intentional, occur frequently in forensic practice. The current case report presented a 43-year-old man with diabetes mellitus with infection, to whom dexamethasone and calcium gluconate were administered in the private clinic. With the development of such clinical symptoms of severe hypokalemia as quadriplegia, he was confirmed to have severe hypokalemia through a biochemical test before dying of arrhythmia. And also it presented pathophysiologic mechanism underlying severe hypokalemia as well as suggestions for clinical practice regarding combination use of dexamethasone and calcium gluconate.
Keywords:forensic pathology  hypokalemia  diabetes mellitus  dexamethasone  calcium gluconate
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