Comparative analysis of two indel-based ancestry informative multiplex PCR typing kits |
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| Institution: | 1. Institute of Legal Medicine, Faculty of Medicine, University of Cologne, Cologne, Germany;2. IPATIMUP – Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal;3. Forensic Genetics Unit, Institute of Legal Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain;1. Laboratorio de Genética Molecular de Cruz Vital – Cruz Roja Ecuatoriana Quito, Ecuador;2. Laboratorio GENES Ltda, Medellin, Colombia;1. Immunological Research, Universy of Cartagena, Cartagena, Colombia;2. Laboratorio GENES Ltda, Medellín, Colombia;3. Instituto de Biología, Universidad de Antioquia, Medellín, Colombia;4. Laboratorio de Genética Molecular, Cruz Roja Ecuatoriana, Quito, Ecuador;5. Universidad Pontificia Bolivariana, Medellín, Colombia;6. IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;1. Armed Forces DNA Identification Laboratory, Armed Forces Medical Examiner System, United States;2. American Registry of Pathology, United States;3. Flinders University, Australia;4. National Institute of Standards and Technology, United States |
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| Abstract: | Two different insertion/deletion (indel) multiplexes have been used to analyse a subset of the CEPH Human Genome Diversity Panel as well as several additional populations collected locally in order to compare the effectiveness of the marker sets in differentiating the populations on a continental level. We show that both marker sets by themselves are able to achieve full continental population differentiation and combining all 67 markers leads to considerably higher accuracy of classification. While differentiation of the European and Middle Eastern population groups remains impossible, surprisingly high accuracy is achieved in assigning Central South Asian samples. |
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| Keywords: | Ancestry AIM Indel |
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