Microhaplotype loci are a powerful new type of forensic marker |
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Institution: | 1. Genetics Department, Yale University School of Medicine, New Haven, CT 06520, USA;2. Human Identification Group, Life Technologies, Foster City, CA 94404, USA;1. Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University, 3-17 Renmin South Road, Chengdu, 610041 Sichuan, China;2. Department of Forensic Genetics, Institute of Forensic Science, Chengdu Public Security Bureau, Chengdu 610081 Sichuan, China;3. College of life Sciences, Sichuan University, Chengdu, 610041 Sichuan, China;4. Bio-resources Key Laboratory of Minister of Education, Sichuan University, Chengdu, 610041 Sichuan, China;1. Department of Genetics, Yale University School of Medicine, New Haven, CT, USA;2. Human Identification Group, Thermo Fisher Scientific, South San Francisco, CA, USA;1. Department of Forensic Genetics, West China School of Basic Science and Forensic Medicine, Sichuan University, 3-17 Renmin South Road, Chengdu 610041, Sichuan, China;2. Department of Forensic Genetics, Institute of Forensic Science, Chengdu Public Security Bureau, Chengdu 610081, Sichuan, China;3. College of Life Sciences, Sichuan University, Chengdu 610041, Sichuan, China;4. Bio-resources Key Laboratory of Minister of Education, Sichuan University, Chengdu 610041, Sichuan, China;1. Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China;2. Department of Forensic Science and Technology, Sichuan Police College, Luzhou 646000, Sichuan, China;3. Department of Forensic Genetics, Institute of Forensic Science, Chengdu Public Security Bureau, Chengdu 610081, Sichuan, China;4. Department of Forensic Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan, China;1. West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China;2. Institute of Forensic Science, Chengdu Public Security Bureau, Chengdu, Sichuan, China |
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Abstract: | Modern sequencing technology makes it possible to genotype polymorphisms with high throughput and high multiplexing. We have searched for and identified many loci with 2 or more SNPs within the expanse of a 200 bp single sequence run and show that when linkage disequilibrium is not complete these loci have multiple alleles detected as phase-known haplotypes. These microhaplotype loci (microhaps) are a powerful tool for individual identification, ancestry inference, and determining family/clan relationships. |
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Keywords: | SNP Haplotype Sequencing Polymorphism Ancestry |
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