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Combined analysis of two different ancestry informative assays using SNPs and Indels in Eurasian populations |
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| Affiliation: | 1. Laboratorio de Genética Molecular de Cruz Vital – Cruz Roja Ecuatoriana Quito, Ecuador;2. Laboratorio GENES Ltda, Medellin, Colombia;1. Flinders Centre for Nanoscale Science and Technology, Flinders University, Sturt Road, Bedford Park, Adelaide, South Australia, Australia;2. School of Biological Sciences, Flinders University, Sturt Road, Bedford Park, Adelaide, South Australia, Australia;1. IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Portugal;2. Faculty of Sciences of the University of Porto (FCUP), Portugal;3. Center of Biological and Natural Sciences, Federal University of Acre (UFAC), Rio Branco, AC, Brazil;4. DNA Diagnostic Laboratory (LDD), State University of Rio de Janeiro (UERJ), RJ, Brazil |
| Abstract: | In the absence of a suspect or DNA database match, small multiplex assays with ancestry informative markers (AIMs) provide an alternative to comparative DNA analysis as the knowledge of an unknown stain donor's biogeographic ancestry can be helpful in guiding criminal investigations. AIMs can provide valuable information in such cases. The research focus for AIMs has been on multiplex assays of single nucleotide polymorphisms (SNPs) and insertion/deletion polymorphisms (Indels). This work presents a combined analysis of two different AIM assays to increase differentiation between Eurasian populations. |
| Keywords: | AIM SNP Indel Ancestry Prediction Forensic DNA Multiplex |
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