| 生物组织检材内异烟肼的薄层色谱扫描检测研究──附1例异烟肼中毒死亡者体内分布报告 |
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| 引用本文： | 王英元,贠克明,李贵明,王玉瑾,张菊亮,张连山.生物组织检材内异烟肼的薄层色谱扫描检测研究──附1例异烟肼中毒死亡者体内分布报告[J].中国法医学杂志,1997(3). |
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| 作者姓名： | 王英元 贠克明 李贵明 王玉瑾 张菊亮 张连山 |
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| 作者单位： | 山西医科大学法医学系!030001(王英元，贠克明，李贵明，王玉瑾)，太原理工大学医院!030001(张菊亮)，山西晋城市郊区公安局!048000(张连山) |
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| 摘 要： | 改进血清中异烟肼的提取方法，建立了生物组织检材内异胭肼的提取和薄层色谱扫描检测方法，线性范围为2～32ug／ml或g，检出限为0．5ug／ml或g。l例异烟擀中毒死亡者体内异烟肼分布：肾31．6mg／100g、肝26．6mg／100g、脾22．1mg／100g、心21．3mg／100g、胃16．6mg／100g、脑15．5mg／100m、肺12．6mm／100g、小脑11．7mm／100g和10.5mm／100ml。
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| 关 键 词： | 异烟肼 薄层色谱扫描 生物组织检材 |
THE DETERMINATION OF ISONIAZID IN BIOLOGICAL TISSUE SPECIMEN BY TLC──DISTRIBUTION OF ISONIAZID IN AN OVERDOSE DEATH |
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| Wang Yingyuan.THE DETERMINATION OF ISONIAZID IN BIOLOGICAL TISSUE SPECIMEN BY TLC──DISTRIBUTION OF ISONIAZID IN AN OVERDOSE DEATH[J].Chinese Journal of Forensic Medicine,1997(3). |
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| Authors: | Wang Yingyuan |
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| Abstract: | The determination of isoniazid(INH) in biological tissue specimen by TLC is reported. INH in bi-ological tissue was derivatized with salicyladehyde and benzaldehyde,and was extracted with ethylac-etate or diethyl ether - dichloromethane (2: 3 ). The standard curves were linear in the range of 2～32ug/ml or g. The limit of detection of the INH in specimen was 0. 5ug/ml or g. The concentrationsof INH in internal organs of a young woman died of INH overdose were as follows: kidney 31. 6mg/100g, liver 26. 6mg/100g, spleen 22. 1mg/100g, heart 21. 3mg/100g, stomach 16. 6mg/100g, brain15. 5mg/100g , cerebellum 11. 2mg/100g and blood 10. 5mg/100ml. |
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| Keywords: | Isoniazid TLC Biological tissue speciman |
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