Methadone extraction from minimal amounts of biological fluids |
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| Authors: | M Chiarotti C Offidani N de Giovanni |
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| Affiliation: | 1. Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY;2. Scott Department of Urology, Baylor College of Medicine, Houston, TX;1. School of Architecture, Harbin Institute of Technology, Harbin, China;2. Key Laboratory of Cold Region Urban and Rural Human Settlement Environment Science and Technology, Ministry of Industry and Information Technology, China;3. School of Energy & Power Engineering, Nanjing University of Science & Technology, Nanjing, China |
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| Abstract: | A new solid phase extraction method was studied to extract methadone from small amounts of biological samples, by using little disposable columns prepacked with reverse phase sorbents. Two different commercial kinds of reversed phase columns prepacked with octadecylsilane (ODS) were tested; the results were compared to those obtained by a direct liquid/liquid extraction method. Gas chromatograms of extracts obtained by means of ODS reversed phase columns showed a good signal/noise ratio resulting in higher sensitivity (20 ng/ml as detection limit), in comparison with the liquid/liquid extraction method. |
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