The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains |
| |
| Authors: | Niijima H Nagao M Nakajima M Takatori T Iwasa M Maeno Y Koyama H Isobe I |
| |
| Affiliation: | Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-0033, Tokyo, Japan. |
| |
| Abstract: | One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
