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| 病毒性心肌炎猝死心肌MCP-1表达及其法医学意义 | |
| 引用本文： | 宁娟,李永宏,张纯兵. 病毒性心肌炎猝死心肌MCP-1表达及其法医学意义[J]. 法医学杂志, 2009, 25(5): 334-336. DOI: 10.3969/j.issn.1004-5619.2009.05.005 |
| 作者姓名： | 宁娟 李永宏 张纯兵 |
| 作者单位： | 1. 皖南医学院法医病理学教研室,安徽,芜湖,241001;华东政法大学司法鉴定中心,上海,200042 2. 皖南医学院法医病理学教研室,安徽,芜湖,241001 3. 华东政法大学司法鉴定中心,上海,200042 |
| 摘 要： | 目的探讨单核细胞趋化蛋白1（monocyte chemoattractant protein-1,MCP-1）在病毒性心肌炎（viral myocarditis,VMC）所致猝死者心肌组织中的表达及其意义。方法运用改良的免疫组织化学方法,观察VMC猝死组和对照组心肌组织中MCP-1的表达情况,应用统计学处理,比较两组间的表达差异。结果20例VMC猝死组中有17例MCP-1染色阳性;而20例非VMC猝死对照组仅4例局部散在MCP-1弱阳性表达,其余均阴性。VMC组MCP-1阳性表达率明显高于对照组（P〈0.01）。结论MCP-1的免疫组织化学检测可作为法医病理学诊断VMC所致猝死较为客观的病理形态学指标之一。 |
| 关 键 词： | 法医病理学 单核细胞化学吸引蛋白质类 猝死,心脏 病毒性心肌炎 |
Expression of Monocyte Chemoattractant Protein-1 in Sudden Death due to Viral Myocarditis and Its Medicolegal Significance |
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| NING Juan,LI Yong-hong,ZHANG Chun-bing. Expression of Monocyte Chemoattractant Protein-1 in Sudden Death due to Viral Myocarditis and Its Medicolegal Significance[J]. Journal of Forensic Medicine, 2009, 25(5): 334-336. DOI: 10.3969/j.issn.1004-5619.2009.05.005 | |
| Authors: | NING Juan LI Yong-hong ZHANG Chun-bing |
| Affiliation: | NING Juan1,2,LI Yong-hong1,ZHANG Chun-bing2(1.Department of Forensic Pathology,Wannan Medical College,Wuhu 241001,China,2.Forensic Expertise Center,East China University of Political Science and Law,Shanghai 200042,China) |
| Abstract: | Objective To explore the expression and significance of monocyte chemoattractant protein-1(MCP-1) in myocardium in sudden death caused by viral myocarditis(VMC).Methods To investigate the expression of MCP-1 in VMC sudden death group and control group using improved immunohistochemical technique and to compare the difference of the expression of MCP-1 between two groups with statistical method.Results In VMC sudden death group,MCP-1 was positively expressed in 17 of 20 cases.While only 4 of the 20 cases in ... |
| Keywords: | forensic pathology monocyte chemoattractant proteins death sudden cardiac viral myocarditis |
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