Updated allelic structures of the DXS10135 and DXS10078 STR loci |
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Authors: | D.R. Sumita M.R. Whittle |
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Affiliation: | Genomic Engenharia Molecular Ltda, R. Itapeva 500/5AB, 01332-903 São Paulo, SP, Brazil |
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Abstract: | DXS10135 and DXS10078 are two highly polymorphic STR loci situated in two different linkage groups on the short arm of the human X chromosome. Both loci comprise complex tetrameric repeat units which may partially explain their high degree of polymorphism. DXS10135 is relatively well characterized and is included in a commercially available kit, while DXS10078 has not been well described. We sequenced a large number of alleles of both loci to try and understand the allelic variation and as a prelude to construct allelic ladders from cloned alleles. Our data show interesting features and should encourage other workers to use these loci in forensic genetic investigations. |
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Keywords: | X chromosome STR Repeat allele structure |
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