广州非洲籍人群15个STR基因座多态性分析

目的调查居住在广州的非洲籍人群的15个STR基因座多态性。方法应用Sinofiler TM荧光标记检测系统对122个无关个体样本进行分型检测,使用Powerstats V12、Genopop 3.4、Mega 3.4等软件进行统计计算与群体间遗传距离比较。结果居住在广州的非洲籍人群15个STR基因座的累积个体识别率为1-5.80147×10-18、累积非父排除率为1-8.6019×10-8,居住在广州的非洲籍人群与广州汉族人群遗传距离最远,与巴哈马群岛非裔混合群体间的遗传距离最近。结论该系统可满足广州地区非洲籍人群个体识别与亲权鉴定的需要,同时与广州汉族人群存在的较大统计学差异,在进行人群区分时具有重要意义。

Genetic polymorphisms of 15 STR loci of Africa population living in Guangzhou

Objective To study the genetic polymorphism of 15 autosomal short tandem repeat(STR)(FGA、vWA、CSF1PO、D3S1358、D5S818、D7S820、D8S1179、D13S317、D16S539、D18S51、D21S11、D2S1338、D19S433、D6S1043、D12S391)loci of the Africa population living in Guangzhou city.Methods 122 unrelated individuals of the Africa population were tested by using SinofilerTM kit,genetic polymorphisms data was analyzed by Powerstats V12、Genopop 3.4、Mega 3.4 software.Results The combined discrimination power(DP) and power of exclusion(PE) is 1-5.80147×10-18 and 1-8.6019×10-8,the Africa population living in Guangzhou city data denotes significant differences for the native Han population in Guangzhou,and is close to the Africa population in Bahamas.Conclusion The SinofilerTM kit is suitable for the Africa population living in Guangzhou in forensic personal identification and paternity test.Furthermore,this population was compared to the native Han population in Guangzhou,showing significant values in the racial distinction.