| 乌头中剧毒生物碱的提取分离 |
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| 引用本文： | 王朝虹,何毅,张继宗,胡春华.乌头中剧毒生物碱的提取分离[J].刑事技术,2002(3):16-17. |
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| 作者姓名： | 王朝虹 何毅 张继宗 胡春华 |
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| 作者单位： | 1. 北京大学药学院,100083
2. 公安部物证鉴定中心,北京,100038 |
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| 摘 要： | 目的从乌头属植物中提取分离剧毒生物碱乌头碱、中乌头碱、次乌头碱;方法酸性水溶液提取,碱化后中性氧化铝柱层析,IR、EI-MS确认结构;结果利用该方法提取以上3种生物碱得到的回收率与碱性苯溶液法相似。结论该方法所用试剂成本低、毒性小,适用于制备乌头碱、中乌头碱、次乌头碱对照品。
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| 关 键 词： | 乌头 乌头碱 中乌头碱 次乌头碱 |
| 文章编号： | 1008-3650(2002)03-016-02 |
| 修稿时间： | 2002年12月8日 |
Separation of toxical aconitum alkaloids |
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| Wang Zhaohong ,He Yi,Zhang Jizong,et al.Separation of toxical aconitum alkaloids[J].Forensic Science and Technology,2002(3):16-17. |
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| Authors: | Wang Zhaohong He Yi Zhang Jizong |
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| Institution: | Wang Zhaohong 1,He Yi,Zhang Jizong,et al |
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| Abstract: | Objective To establish a method for extracting and separating mesaconitine,aconitine and hypaconitine.Methods Aconitum kusnezoffii reichb was extracted with0.2mol/L HCl and adjusted to pH10.The precipitate was chromatographed over neutral alumina.Each alkaloid's structure was identified with IR and EI-MS.Results The recovery received from this method was similar with that of ammoniacal benzene method.Conclusion This method was at low cost,harmless and suitable for preparing mesaconitine,aconitine and hypaconitine. |
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| Keywords: | aconitum aconitine mesaconitine hypaconitine |
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