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家兔非热低压电击伤血清LDH和HBDH活性的动态变化
引用本文:步建衡,靳彦奎,谷建平. 家兔非热低压电击伤血清LDH和HBDH活性的动态变化[J]. 中国法医学杂志, 2009, 24(2): 87-89
作者姓名:步建衡  靳彦奎  谷建平
作者单位:1. 河北省公安厅,河北,石家庄,050051
2. 石家庄市人民检察院,河北,石家庄,050090
3. 河北省人民检察院,河北,石家庄,050000
摘    要:目的研究家兔非热低压电击伤后不同时相乳酸脱氢酶(lactate dehydrogenase,LDH)和羟丁酸脱氧酶(hydroxybutyrate dehydrogenase,HBDH)活性的变化,为临床和法医学非热电击伤提供诊断依据。方法健康新西兰大白兔40只,随机分为对照组和电击伤后7个时间点的实验组,每组5只。实验各组家兔用220V 50Hz交流电电击2S后自由进食,按照预定时间点麻醉后抽取心室血5mL,使用自动生化仪(type Selectra-2)测定血清LDH、HBDH酶活性。对照组家兔不电击,其他处理同实验组。结果实验组家兔目标血清酶活性发生了动态变化,有一定规律性,LDH活性在电击后4h,12h,1d,2d,3d明显升高(4h,12h,1dP〈0.01;2d,3dP〈0.05);HBDH活性在电击后2d、3d明显升高(P〈0.05);HBDH/LDH比值在2h、4h、12h与对照组比较显著降低(P〈0.01)。结论动态监测LDH、HBDH活性,可为非热电击损伤的诊断、损伤时间推断提供理论依据。

关 键 词:法医病理学  电击伤  乳酸脱氢酶  羟丁酸脱氢酶

An unstatic experiments of LDH and HBDH activities in rabbit serum after electrical injury
BU Jianheng,JIN Yankui,GU Jianping. An unstatic experiments of LDH and HBDH activities in rabbit serum after electrical injury[J]. Chinese Journal of Forensic Medicine, 2009, 24(2): 87-89
Authors:BU Jianheng  JIN Yankui  GU Jianping
Affiliation:BU Jianheng, JIN Yankui, GU Jianping(1. Public Security Department of Hebei Provincial, Shijiazhuang 050051, China; 2. Shijiazhuang municipal People's Procuratorate, Hebei 050000, China; 3. Hebei People's Procuratorate , Shijiazhuang 050000, China)
Abstract:Objective Observing the phase changes of lactate dehydrogenase (LDH) and hydroxybutyrate dehydrogenase (HBDH) activities, so as to provide a basis of diagnosis of electric injury for clinic and forensic medicine cases. Methods The experimental animals were composed of 40 Healthy New Zealand rabbits and divided into eight groups with 5 rabbits for each: one control group and seven electric-shocked groups treated in different time points (0h, 2h, 4h, 12h, 1d, 2d, 3d) with electric injury. 5 mL of ventricle bl...
Keywords:forensic pathology  electrical injury  LDH  HBDH  
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