A fatal dothiepin overdose |
| |
| Affiliation: | 1. Rennes University Hospital, Department of Clinical and Biological Pharmacology and Pharmacovigilance, Pharmacoepidemiology and Drug Information Centre, Rennes, France;2. Rennes 1 University, Faculty of Medicine, Laboratory of Experimental and Clinical Pharmacology, Rennes, France;3. Inserm, CIC-P 1414 Clinical Investigation Centre, Rennes, France;4. Paris Sud University, Faculty of Pharmacy, EA4123 Barrières physiologiques et réponses thérapeutiques, Châtenay-Malabry, France;5. Cochin Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Pharmacokinetics and pharmacochemistry Department, Paris, France;6. Rennes University Hospital, Liver Disease Unit, Rennes, France;7. Saint-Antoine Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), Pharmacy Department, Paris, France;8. Rennes University Hospital, Intensive Care Medicine Unit, Rennes, France;9. Rennes University Hospital, Haematology Department, Rennes, France;10. Paris Descartes, Sorbonne Paris Cité University, Faculty of Pharmacy, Biomathematics Laboratory, Paris, France;11. Inserm, Paris Descartes University, Paris Diderot University, UMR-S 1144, Paris, France;12. Rennes University Hospital, Department of Hepatobiliary and Digestive Surgery, Rennes, France;1. Harvard Medical School Department of Psychiatry at Beth Israel Deaconess Medical Center, Boston, MA, USA;2. Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai, China;3. Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA;4. New York University College of Global Public Health, New York, NY, USA;5. Department of Psychiatry, Columbia University, New York, NY, USA;6. New York State Psychiatric Institute, New York, NY, USA |
| |
| Abstract: | High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (ProthiadenR) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
