Detection of cocaine and its polar transformation products and metabolites in human urine |
| |
| Affiliation: | 1. Future Industries Institute, University of SA, Australia;2. National Institute of Chemical Physics and Biophysics, Tallinn, Estonia;3. University of Tartu, Tartu, Estonia;4. CSIRO Mathematical and Information Sciences, Australia;5. Centre for Environmental Risk Assessment and Remediation, University of SA, Australia;1. Kanchi Mamunivar Government Institute for Post Graduate Studies and Research, Puducherry 605 008, India;2. Rajiv Gandhi Arts and Science College, Thavalakuppam, Puducherry, 605 007, India;3. Department of Chemistry, Pondicherry University, Puducherry 605 014, India;4. Department of Physics, S.A. Engineering College, Chennai, 600 077, India |
| |
| Abstract: | This paper describes a method for the analysis of thermal degradation compounds generated from cocaine during the smoking process, together with chemical and enzymatic biotransformation products which, by virtue of their polarity, are not recovered by existing analytical procedures. The method employs cation exchange solid phase extraction coupled with gas chromatography/mass spectrometry. Compounds identified in urine from subjects of cocaine-related death included cocaine, benzoylecgonine, ecgonine methyl ester and ecgonine, which were measured quantitatively, and ecgonidine, ecgonidine methyl ester, ecgonine ethyl ester, ethyl benzoylecgonine, norcocaine, benzoylnorecgonine, cinnamoylcocaine, and cinnamoylecgonine. The concentrations of ecgonine (0–104 μg/ml) and ecgonine methyl ester (0–177 μg/ml) were substantial and averaged about one tenth the concentrations of benzoylecgonine (0–1074 μg/ml) and cocaine (0–1221 μg/ml). These and several of the other compounds identified will be valuable markers for cocaine use, in degraded samples and for indicating the route of administration. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
