Genetic ancestry in Afro-descendants from the Andes and Pacific Coast regions of Ecuador |
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| Affiliation: | 1. Facultad de Medicina, Universidad de Las Américas (UDLA), Quito, Ecuador;2. Grupo de Medicina Xenómica. Instituto de Ciencias Forenses, Universidad de Santiago de Compostela, Spain;3. One Health Research Group, Facultad de Medicina, Universidad de las Américas, Quito, Ecuador;4. IPATIMUP, Institute of Pathology and Molecular Immunology from University of Porto, Portugal;5. i3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Portugal;6. DNA Diagnostic Laboratory, State University of Rio de Janeiro, Rio de Janeiro, Brazil;7. FCUP, Faculty of Sciences, Department of Biology, University of Porto, Portugal;8. Laboratorios de Investigación, Universidad de Las Américas (UDLA), Quito, Ecuador;9. Carrera de Biotecnología, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Américas (UDLA), Quito, Ecuador;10. Escuela de Medicina, Facultad de Ciencias Médicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador;11. Instituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Ecuador;12. Grupo de Bio-Quimioinformática, Universidad de Las Américas (UDLA), Quito, Ecuador;13. Carrera de Enfermería, Facultad de Ciencias de la Salud, Universidad de Las Américas (UDLA), Quito, Ecuador |
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| Abstract: | This study aimed to investigate genetic diversity and ancestry in Afro-descendants from the Andes (AN) and the Pacific Coast (PC) regions of Ecuador, using autosomal and lineage markers. CR-mtDNA and PPY23-STRs showed high haplotype diversities. Statistically significant differences were found between AN and PC. Due to different patterns of sex-biased matting, differences between regions were more pronounced for the mtDNA than for the Y-chromosomal markers. A lower African ancestry was detected in AN than PC, for autosomal and both maternal and paternal lineage markers. |
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| Keywords: | AIM-Indels Y-STRs CR-mtDNA Afro-descendants Ecuador |
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