| 大鼠海绵体神经的解剖及神经性ED模型的建立 |
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| 作者姓名： | Wang FX Zhang LL Zhu GY |
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| 作者单位： | 1. 华中科技大学同济医学院法医学系,湖北,武汉,430030
2. 司法部司法鉴定科学技术研究所,上海,200063 |
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| 摘 要： | 目的对大鼠海绵体神经进行解剖并制作损伤致神经性ED的动物模型。方法通过10只废弃大鼠的解剖了解海绵体神经的解剖结构,将30只雄性SD大鼠分为实验组和对照组,术后一个月通过低频电刺激证实造模是否成功。结果大鼠海绵体神经解剖结构与人体非常相似,位于盆神经节的下方,电刺激海绵体神经,勃起试验阳性,造模后勃起试验阴性(P<0.01)。结论由于大鼠海绵体神经分布与人体有高度相似性,且价格适合,是ED研究的理想动物,海绵体神经损伤是建立神经性ED的可靠方法。
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| 关 键 词： | 海绵体神经 勃起功能障碍 大鼠 |
| 文章编号： | 1004-5619(2006)03-0183-03 |
| 修稿时间： | 2005年10月26 |
Dissection of cavernous nerves in rat and model of neurological erectile dysfunction |
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| Wang FX,Zhang LL,Zhu GY.Dissection of cavernous nerves in rat and model of neurological erectile dysfunction[J].Journal of Forensic Medicine,2006,22(3):183-185,F0004. |
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| Authors: | Wang Fei-Xiang Zhang Ling-Li Zhu Guang-You |
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| Institution: | Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
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| Abstract: | Objectives To identify rat cavernous nerve and establish a rat model of erectile dysfunction caused by injury of cavernous nerve. Methods Ten rats were undergone dissections. 30 experimental rats were randomized into 2 groups, cavernous nerve were identified by electrical stimulation. One month after surgery, rat models were evaluated by electrical stimulation. Results The anatomic structure of cavernous nerve in rats are highly similar to human beings, the erection can be evoked by stimulating cavernous nerves, and after cavernous nerve injury it can not be evoked(P<0.05). Conclusion Because of the highly similarity of cavernous nerve between rats and human beings, so as the suitable price, rat should be used as the ideal ED experimental animal. The model of ED caused by cavernous nerve injury is reliable. |
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| Keywords: | cavernous nerve erectile dysfunction rat |
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