Heroin impurity profiling. A harmonization study for retrospective comparisons

Three laboratories present a harmonised system for the retrospective comparison of south west Asian heroin. It consists of an improved gas chromatographic (GC) profiling method and a computerised data retrieval. The investigations of the GC were necessary with a view to improve the reproducibility of the system. The necessity of a strict quality control is emphasized. The peaks of the GC profile were investigated for abundance, intensity, GC behaviour (reproducibility) and correlations; 16 of them were selected for describing the heroin profile in the database. The results from intra-lab profile comparisons are reported. The reproducibility of the analysis was good and the variation between the samples was large, thus, allowing conclusions with a high degree of certainty. The criteria of similarity were defined. The system is successfully running in all three labs.In connection with inter-laboratory comparison, the aspects of method harmonisation and standardisation are discussed. It appeared that the GC method is a very subtile one, urging for a strict standardisation between the three labs. Despite a long cooperation between three well-equipped and experienced labs, a more or less serious loss of reproducibility was noticed in the inter-lab results in comparison with the intra-lab results. The loss could for the greater part be attributed to the (limits of the) GC technique; a number of compounds, necessary for making the discrimination between samples, showed difficult chromatographic behaviour, leading to insufficient inter-lab reproducibility. Using the actual variables, improvements in performance can hardly be expected in the near future. The loss of reproducibilty implies that the number of false positive matches in a database search increases. This may strongly reduce the value of a relatively large, international database. The study shows that so far, the best option for international comparison is the analysis in a central laboratory. The idea of local determination at a large number of national labs and the use of a common database is not a realistic aim for this type of analysis.     

In Person

An Associate Professor in the Law Department of the prestigiousEDHEC Business School, Nice, Cedric Manara is one of the liveliestand most influential intellectual property educators and opinion-makersto emerge from France in recent     

State legislative approaches to regulating the use of genetic information

As genetic testing becomes more prevalent and the uses for genetic information multiply, we are likely to witness more demand for comprehensive state legislation on the order of the Oregon law regulating the procedures for obtaining and using genetic information. In addition, the United States Senate has expressed an interest in the subject. The Senate Labor and Human Resources Committee reportedly agreed on August 2, 1995 to include in a health insurance reform bill (S. 1028) language prohibiting health plans from using genetic information when determining eligibility, continuation, enrollment, or contribution requirements. 4 BNA's Health Law Rep. at 1218 (Aug. 10, 1995). Insurance companies continue to maintain that genetic test results are simply another factor that should rightfully be used during underwriting, much as age, medical history, and physical examinations are routinely used today. Right to privacy advocates argue that genetic testing provides employers and insurance companies with too much information and offers a great potential for discrimination. As more states wrestle with this issue, these competing interests are likely to be debated in public forums throughout the country.     

Telemedicine--the diagnostic tool of the future

The most immediate concern in the development of telemedicine programs, technology, and equipment is the continuation of federal funding. As Congress continues its efforts to balance this year's federal budget, funds for research generally and particularly for the pilot programs discussed above could be cut or eliminated. Federal funding is surprisingly important to the rapid maturation of telemedicine. Without these pilot projects, HCFA believes that it would be unable to assess the effect of Medicare reimbursement for telemedicine consultations. Without such assessment, HCFA may be unwilling to relax the current restrictions on reimbursement for telemedicine outside of pilot programs. HMOs and third-party payors would then be less likely to support telemedicine programs and reimburse providers who participate in them. Similarly, without the promise of federal or private reimbursement, the telecommunications industry will find it harder to justify continuing research and development in new technologies. Nonetheless, even a complete elimination of all federal research monies is likely only to slow the growth of telemedicine, not stop it.     

20世纪末以来中、美与东盟的三边互动关系——以权力转移为视角

中国的崛起对美国和东盟均产生重大影响,导致中、美和东盟在经贸、政治和认知方面形成了互动关系。由于经济领域的区域经济一体化、贸易转移效应和政治领域东亚一体化的排斥效应等因素,中美在东亚的权力关系发生了转移,东亚秩序经历了结构性调整。三方在经贸、政治和认知的互动相互影响并呈正相关关系,使得东亚的权力转移在和平中实现。互动中仍存在一些问题需要三方调适和合作加以解决。     

全球减排路线图的正义性——对胡鞍钢教授的全球减排路线图的评价与修正

任何全球减排路线图的绘制都无法脱离国际正义而具有生命力。气候变化问题的特性要求全球减排路线图尊重具有两面性的国际气候正义:环境正义和发展正义,需要考虑国家间公平、人的公平和代际公平。仅以人类发展指数(HDI)作为衡量国家承担减排责任的标准缺乏足够的正义,至少还需要加入人均历史累积排放和气候变化脆弱性两个指标。三者分别体现气候变化正义性中的人的平等发展权、减排责任分担和对受害者在排放权上的补偿。综合三大指标后的四分组分类,才是更体现正义性、更容易被接受和执行的路线图。从正义性出发,中国应承担相应的减排责任,并努力推动全球减排进程,但也要注意维护自身的发展权益。中国在全球减排中的作为,应是在国际正义与国家发展战略间取得平衡。     

中苏(俄)关系的历史演进及其当前启示

从中苏到中俄,从同盟、对抗到伙伴,这三种关系模式如同历史本身的有机发展一样,彼此之间有着深厚的逻辑关联。一方面,同盟和对抗模式为伙伴模式提供了极为丰厚的历史遗产,对其产生了不可割舍的内在影响和制约。另一方面,伙伴模式在20世纪90年代后之所以能够得到全面、持续而又深入地构建,是与其对同盟和对抗模式所进行的辩证继承和扬弃分不开的。