广东战略性新兴产业空间布局研究——基于因子分析法和聚类分析法

研究广东战略性新兴产业的空间布局对于广东实现产业结构升级和转变经济发展方式意义重大。该文介绍了战略性新兴产业空间布局的三种基本模式,在此基础上,运用因子分析法和聚类分析法对广东省战略性新兴产业的空间聚类进行实证分析,对广东21个地级市进行空间布局模式的划分,并从布局机制、布局模式、布局区位以及布局策略等方面为科学布局广东战略性新兴产业提出政策建议。     

山西参与国际区域经济合作的现状及环境因素分析

山西对外经济在"十一五"期间取得了较大发展,但也存在一些问题,比如对外贸易总量仍然偏低;出口逆差增加;利用外资规模偏小,总体水平偏低;利用外资产业面窄;外商直接投资的聚集效应不明显;高新技术区对全省高新产业的带动作用有限,等等。"十二五"期间,山西要扩大国际区域经济合作的范围,优化参与路径,面临着外部及内部两种因素的影响。外部因素主要是国际区域经济一体化趋势的加快以及中国自贸区政策的深入推进,内部因素主要有山西必须进行的资源型经济转型以及转型跨越带来的新机遇。     

丰富环境对脑梗死大鼠梗死灶周围血管内皮生长因子受体的影响

目的:研究丰富环境对大鼠局灶性脑梗死后梗死灶周围血管内皮生长因子受体的影响.方法:采用开颅电凝法制作SD大鼠右侧大脑中动脉缺血(MCAO)模型,术后第24小时随机分为丰富环境(EE)组和标准环境(SE)组.以免疫组织化学法检测血管内皮生长因子受体Flt-1及Flk-1的表达.结果:大鼠大脑中动脉闭塞后,缺血区神经元变性、坏死,Flt-1和Flk-1在缺血周边区表达明显增加,经丰富环境干预后,血管内皮生长因子受体表达大量增加.结论:丰富环境可促使血管内皮生长因子受体表达上调,进而促进微血管新生,有利于脑损伤修复.     

The association between body mass index and pulmonary thromboembolism in an autopsy population

Abstract: To evaluate the association between obesity and pulmonary thromboembolism (PTE) in a forensic context, 160 autopsy cases of fatal PTE were compared with age‐ and gender‐matched controls. The mean age of cases was 66 years (range 26–98 years; M/F 74:86). The mean body mass index (BMI) of cases with PTE was 30.88 (range 14.95–79.51), which was significantly higher than in the controls (mean BMI = 25.33; range 12.49–61.84) (p < 0.0001). Comparing the group with PTE with controls showed that five (3.1%) compared to 20 (12.5%) were underweight, 39 (24.4%) compared to 67 (41.88%) were of normal weight, 49 (30.63%) compared to 43 (26.88%) were overweight, 43 (26.88%) compared to 24 (15%) were obese, and 24 (15.0%) compared to six (3.75%) were morbidly obese. In each category of above‐normal BMIs, there were significantly greater numbers in the groups with PTE: overweight (p < 0.01), obese (p < 0.001), and morbidly obese (p < 0.0001).     

马克思主义大众化研究中需要注意的几个问题——以重庆市机关人员的调查问卷为基础

当前马克思主义大众化研究正处在拓展与反思相结合的阶段,反思的深度直接决定了今后研究的重点和方向。通过对重庆市机关人员的调查研究发现,马克思主义大众化研究中要重视下述四个问题：人民群众陷入马克思主义信仰危机的说法是对马克思主义大众化的重大误解;阻碍马克思主义大众化的重要因素不在理论界,而在于党内的腐败现象;与网络、广播、电视、动漫等显性载体相比,党员干部的工作作风这一隐性载体更为重要;在马克思主义大众化的宣传手段中除了要重视“术”的运用外。更要重视对“加强人文关怀”这一“道”的遵循。     

A closer look at risk factors for public-private partnerships in Singapore: six case studies

ABSTRACT

Despite its global popularity over the past few decades, the public-private partnership (PPP) has not always led to successful outcomes, due largely to a number of risk factors associated with the projects. To explain how and why PPPs sometimes fail, this study considers the success-failure continuum of Singapore’s recent PPP experience from 2000 to 2019. After taking a critical, close look at the six failed cases, we identify the following latent risk factors: unstable financial capacity during the execution period of a project, force majeure unforeseen problems that arise, a lack of technical and/or financial foresight, poor corporate management (e.g. delays in construction and poor-quality service delivery), and an unfavourable investment environment stemming from the lack of a clear and supportive governance framework. In addition, we find that most risk factors tend to appear during the contract management (pre-operation) and project management (operation) phases. Such risks seem to drive the operational failure and subsequent contract termination of multiple unsuccessful PPPs, simultaneously (and sometimes sequentially) rather than in isolated fashion. All in all, this study offers for policymakers that better risk allocation and proper, mutual coordination between the public and private partners represent essential factors for PPP success.     

901例社区2型糖尿病血瘀证的影响因素研究

目的 了解血瘀证在社区2型糖尿病患者中的分布及其相关影响因素。 方法 以社区901例2型糖尿病患者为研究对象,采集其相关临床信息并进行中医辨证分析,采用单因素分析和Logistic回归分析考察血瘀证的影响因素。 结果 901例2型糖尿病患者中,单纯血瘀脉络证165例,阴虚热盛证、湿热困脾证、气阴两虚证、阴阳两虚证分别为137、135、334、130例,分别兼夹血瘀证55、57、200、101例,各证型兼夹血瘀证的比例明显不同（P<0.05）。单因素分析结果显示,年龄、病程、高血压并发症、收缩压、体质量、体型是血瘀证的影响因素,舒张压、血脂水平不是血瘀证的影响因素;二项分类Logistic回归分析结果显示,年龄、高血压并发症、收缩压是血瘀证的影响因素。 结论 血瘀证是社区2型糖尿病患者的主要证型,年龄越大,具有高血压并发症,收缩压较高者易于出现血瘀证,尚不能认为病程、体质量和体型是2型糖尿病血瘀证的影响因素。     

补肾安胎冲剂对复发性自然流产小鼠蜕膜血管内皮生长因子及其受体调控作用研究

目的 观察补肾安胎冲剂对复发性自然流产（recurrent spontaneous abortion,RSA）小鼠胚胎丢失率和蜕膜组织血管内皮生长因子（vascular endothelial growth factor,VEGF）及其受体的影响。方法 采用Clark经典RSA小鼠模型,将RSA小鼠随机分为模型组、补肾安胎冲剂低剂量（11.7 g/kg）组、补肾安胎冲剂高剂量（23.4 g/kg）组,黄体酮胶囊（156 mg/kg）组,另取正常妊娠小鼠作为正常组,每组8只。末次给药后,处死小鼠,计算胚胎丢失率;光镜下观察蜕膜组织血管形态学改变;采用免疫组化法检测蜕膜组织VEGF、血管内皮生长因子受体2（vascular endothelial growth factor receptor 2,VEGFR-2）、可溶性血管内皮生长因子受体-1（soluble vascular endothelial growth factor receptor 1,sVEGFR-1）的表达;采用RT-PCR法检测小鼠蜕膜组织中VEGF、VEGFR-2及sVEGFR-1 mRNA的表达。结果 补肾安胎冲剂能改善蜕膜组织血管形态学变化,升高蜕膜组织中VEGF和VEGFR-2蛋白含量,降低sVEGFR-1蛋白含量;能显著降低RSA小鼠胚胎丢失率（P<0.05）,升高蜕膜组织中VEGF和VEGFR-2 mRNA表达水平,降低sVEGFR-1 mRNA表达水平（P<0.05）,呈现明显的量效关系。结论 补肾安胎冲剂对RSA小鼠具有一定的保护作用,其机制可能与调控VEGF及其受体,改善蜕膜组织血管重铸有关。     

GFAP和VEGF在创伤性脑损伤中表达的研究进展

创伤性脑损伤是世界上导致死亡及残疾的主要原因之一。检测对中枢神经系统损伤有高度特异性和敏感性的生物标志物,可以在一定程度上反映损伤情况。胶质纤维酸性蛋白与血管内皮生长因子均可作为颅脑损伤的生物学标记物,其表达变化规律、峰值出现时间,与创伤性脑损伤的严重程度及损伤时间的推断密切相关,对于法医病理学具有重大意义。该文对胶质纤维酸性蛋白与血管内皮生长因子的分子生物学特性及其在创伤性脑损伤中的表达进行综述。     

Construct validity and internal reliability of the Finnish risk and needs assessment form

Validation of risk and needs assessment instruments used to predict, and reduce, recidivism and misconduct is of ethical, practical and scientific importance. We argue for a focus on variable (i.e. changeable over time) risk factors, and that validation begins with establishing construct validity. The Finnish Risk and Needs Assessment Form, in Finnish Riski- ja tarvearvio (RITA), is a semi-structured interview form adapted from the Offender Assessment System used in England and Wales and consists primarily of variable risk factors. In this study, we examined the construct validity and internal reliability of RITA. The results suggest that the original RITA sections do not provide an adequate statistical model for describing the relationship between scored questions, and we, therefore, offer an improved model. In our proposed model, several scores are influenced by more than one dimension of risk and the dimensions correlate with each other considerably. We suggest that the dimensions that can be measured with RITA are Problems managing economy, Alcohol problems, Resistance to change, Drug abuse and associated behaviour, Aggressiveness and Employment problems. All factors except Drug abuse and associated behaviour had very good internal reliability. We propose this new model to be used in future research with, and in development of, RITA.