Plasma,oral fluid and sweat wipe ecstasy concentrations in controlled and real life conditions

In a double-blind placebo controlled study on psychomotor skills important for car driving (Study 1), a 75 mg dose of +/- 3,4-methylenedioxymethamphetamine (MDMA) was administered orally to 12 healthy volunteers who were known to be recreational MDMA-users. Toxicokinetic data were gathered by analysis of blood, urine, oral fluid and sweat wipes collected during the first 5h after administration. Resultant plasma concentrations varied from 21 to 295 ng/ml, with an average peak concentration of 178 ng/ml observed between 2 and 4h after administration. MDA concentrations never exceeded 20 ng/ml. Corresponding MDMA concentrations in oral fluid, as measured with a specific LC-MS/MS method (which required only 50 microl of oral fluid), generally exceeded those in plasma and peaked at an average concentration of 1215 ng/ml. A substantial intra- and inter-subject variability was observed with this matrix, and values ranged from 50 to 6982 ng/ml MDMA. Somewhat surprisingly, even 4-5h after ingestion, the MDMA levels in sweat only averaged 25 ng/wipe. In addition to this controlled study, data were collected from 19 MDMA-users who participated in a driving simulator study (Study 2), comparing sober non-drug conditions with MDMA-only and multiple drug use conditions. In this particular study, urine samples were used for general drug screening and oral fluid was collected as an alternative to blood sampling. Analysis of oral fluid samples by LC-MS/MS revealed an average MDMA/MDEA concentration of 1121 ng/ml in the MDMA-only condition, with large inter-subject variability. This was also the case in the multiple drug condition, where generally, significantly higher concentrations of MDMA, MDEA and/or amphetamine were detected in the oral fluid samples. Urine screening revealed the presence of combinations such as MDMA, MDEA, amph, cannabis, cocaine, LSD and psilocine in the multiple-drug condition.     

Leaving Europe: New Crises,Entrenched Inequalities and Alternative Routes of Social Mobility

Abstract

This article addresses conceptual issues around contemporary forms of out-of-Europe migrations of various European publics. In particular, we ask how such moves contribute to both the decentring of Europe in migration debates, and to the ‘de-migranticization' (Dahinden, 2016 Dahinden, J. (2016). A plea for the ‘de-migranticization’ of research on migration and integration 1. Ethnic and Racial Studies, 39(13), 2207–2225. https://doi.org/10.1080/01419870.2015.1124129[Taylor & Francis Online], [Web of Science ®] , [Google Scholar]) of the social scientific study of migration. This article also serves as the introduction to this special issue entitled “Leaving Europe: Alternative routes of up/outward mobility” that aims to document ethnographically new forms of European emigration and shed light on an imaginary of Europe which is not conceived as a place of prosperity and success but rather as a locus of disempowerment.     

Business as usual

The tech stock crash of 2000 discredited the new economy as business model. This article introduces a journal special issue which takes up the challenge of putting new economy developments into this post-crash perspective and establishing long-run continuities, without discounting the importance of what happened. This article opens the debate by highlighting two themes in the articles that are collected together in the special issue: first, it discusses what was and is the new economy in the USA; second, it examines the relevance and resonance of the new economy in Europe.     

Shareholder value and Financialization: consultancy promises,management moves

In the pages of the daily financial press, 'shareholder value' is a loose rhetoric. For business consultants who sell financial metrics and implementation, shareholder value is also a product and a promise that purposive management action will be rewarded. This paper begins by considering the consultant's promise and the more guarded academic responses. It then presents empirics on micro performance and the meso limits to shareholder value and argues that most corporate managements cannot easily deliver what consultants promise and the capital markets demand. The paper ends by taking a broader view of value-based management as part of a process of financialization. If the results are contradictory and disappointing, a persistent gap between expectations and outcomes can nevertheless drive management behaviours, which change the world.     

Determination of blood/serum ratios of different forensically relevant analytes in authentic samples

For forensic toxicological investigations only whole blood, but no serum is often available. Pharmacokinetic data are helpful for interpreting the results, but most of these studies indicate serum or plasma concentrations. In order to obtain reliable conversion factors which also take intersubject variability into account, the blood/serum ratios (B/S) of oxycodone, morphine, fentanyl, hydromorphone, zopiclone, MDMA, dexamphetamine, alprazolam, risperidone and 9-hydroxyrisperidone were determined by LC-MS/MS using authentic samples. Blood and corresponding serum samples were obtained from driving studies performed with controlled or known dosages of the above drugs. The analytes were analysed in blood and serum and the following mean B/S ratios (relative standard deviations) were determined: oxycodone 1.48 (8.19 %); morphine 1.03 (3.59 %); fentanyl 0.87 (13.9 %); hydromorphone 1.04 (8.11 %); zopiclone 0.89 (16.1 %); MDMA 1.19 (8.04 %); dexamphetamine 0.89 (10.9 %); alprazolam 0.81 (5.84 %); risperidone 0.65 (7.52 %); 9-hydroxyrisperidone 0.73 (12.3 %). These mean values are largely in line with those reported in the literature. The B/S ratios did not appear to depend on partition coefficients, whereas there was strong evidence that B/S ratios decreased with increasing plasma protein binding.     

Accounting for failure in the nationalised enterprises — coal,steel and cars since 1970

This paper analyses the nature of the strategic miscalculations in nationalised British coal, steel and cars since the early 1970s. Specifically, it examines the extent to which the initial strategic miscalculations were caused by an uncritical use of return on investment (ROI) techniques and the extent to which subsequent operational retreat was determined by profit and loss considerations. The general conclusion is that financial (mis)calculation was a secondary problem in enterprises which did not identify their productive problems and could not solve their market difficulties. In our three cases, large-scale investment was futile when the state did not safeguard the market for the final product.     

British Pharmaceuticals: a cautionary tale

British pharmaccuticals is generally represented as a successful sector which illustrates the potential of knowledge-intensive, high-valve-added activities. This article presents a revisionist account based on evidence and argument. Pharmaceuticals is a small sector which combines high-value-added and average wages to benefit capital not labour. The knowledge base in the laboratory creates imitative product with marketing then applied to capture social expenditure. When product-market growth slows, the sector restructures defensively without solving its problems.     

Reconceptualizing financial innovation: frame,conjuncture and bricolage

Abstract

This article argues for a reconceptualization of financial innovation which, as culprit and victim of the current crisis, is now damned by those who once praised it. But what is financial innovation? The dominant answers from mainstream finance and social studies of finance share variations on a rationalistic view whereby financial innovation is about improving markets or at least extending the sphere of rational calculability. Because improvisation is more important than the dominant perspectives can admit, this article proposes a new concept of financial innovation whose three main elements – frame, conjuncture and bricolage – are indicated by the title of this article. The importance of this problem shift is that it highlights the inherent fragility of this type of intermediary-led financial innovation where things will often miscarry and highlights the need for a more radical rethinking about policy responses to the financial crisis that began in 2007.     

The Causes of Disease Impact Denialism in Nicaragua's Response to COVID-19

The response of the Nicaraguan government to the COVID-19 emergency is an extreme case of disease denialism. Such denialism is a major threat to public health, so understanding the sources of this attitude is paramount. Three explanations are offered: (a) the autonomous logic of a polarised political conflict; (b) an explanation based on an economic rationale; and (c) the regime's mystical and religiously-inspired discourse. The denialist response of the government is inexplicable without referring to the characteristics of the political regime, its political discourse and its recent developmental trajectories since the massive 2018 protests and the ensuing political conflict.