An autopsy case of imipramine poisoning

We present a fatal imipramine poisoning. Quantitative analysis of imipramine and its metabolite, desipramine, was performed by high-performance liquid chromatography. The concentrations of imipramine and desipramine were 18.67 microg/mL and 6.21 microg/mL in heart blood and 6.90 microg/mL and 1.77 microg/mL in the femoral venous blood, respectively. We concluded that the cause of death was due to imipramine poisoning.     

Postmortem ophthalmologic examination by endoscopy

Abnormal intraocular findings detected during forensic autopsies have generally been ignored. In this study, we assessed the usefulness of postmortem ophthalmologic examination in 46 cases using an endoscope system with a tip diameter of 0.9 mm. This procedure was performed using a portable system, and only 1 assistant was needed. Furthermore, the procedure required only about 5 minutes for both eyes. Abnormal intraocular findings were seen in 22 (47.8%) of 46 cases. Fundus hemorrhages were observed in 4, and papilledema was observed in 3 of 5 cases of death due to head trauma; besides, it was possible to estimate the interval between head trauma and death based on intraocular findings. Seven of 16 cases of death from asphyxia presented abnormal intraocular findings, including retinal splinter hemorrhages. Fundus hemorrhages were observed in 2 of 3 cases of death by drowning, which, to our knowledge, had never been reported to date.Thus, this procedure proved easy to perform, and it may be useful to detect significant abnormal intraocular findings related to the presumed cause of death during autopsies.     

Thymus and adrenal glands in elder abuse

Endogenous glucocorticoid-induced thymic involution is generally considered to be an important finding for determining child abuse. The present study investigated the weight of the thymus and the adrenal glands in elder abuse cases to identify a potential marker for elder abuse. There was no significant difference in the thymus and the adrenal weight between elder abuse and control cases. However, the elder abuse cases in which the duration of abuse was less than 3 months showed a significant increase in the adrenal weight in comparison to control cases. In such cases, histopathological findings showed a loss of intracellular light granules from the zona fasciculata, which might indicate a loss of cholesterol due to the overproduction of glucocorticoid. These results might imply that the elderly, who were maltreated for less than 3 months, were in the early phase of a long-term stress state during which stress-induced overproduction of glucocorticoid was observed in adrenal glands as indicated by Selye. Our results suggest that an increase in adrenal weight may be a potential marker for elder abuse of relatively short periods, especially less than a few months.     

Reinvigorating the transnational links of sub-national governments between Australia and Japan with special reference to Western Australia–Hyogo sister-state relations

Abstract

The study of transnational links between sub-national governments is a lacuna in the field of international relations yet the issue on inter-sub-national government cooperation has recently gained greater importance at the international level. Since the 1992 Earth Summit recognition of sub-national authorities as key players in global sustainable development strategies, the importance of decentralised cooperation between sub-national governments has been strengthened by a series of international standardisation and domestic incorporation of this principle. Yet our research raises serious questions about the degree to which Australia–Japan twinning of sub-national governments has made progress towards taking responsibility in facing global challenges. Our case study of Western Australia–Hyogo sister-state relationships shows that their 25 year-old cooperation has been suffering from a lack of awareness of the emerging role of sub-national governments. Not surprisingly, national government policy and position has greatly influenced the nature and patterns of their relationships. Australia and Japan twinning, as leading inter-sub-national partnerships in the region, can do more to promote the value of the local dimension in international development cooperation. In light of these challenges, the future of their twinning must lie in a structured long-term commitment for global strategies as well as mutual benefits.     

Subnational participation in extra-national policy solutions: Kitakyushu City as an intermediate agent in policy coordination

The growing challenges of environment and sustainable development stretch across scales of geographic space and require action at multiple levels of jurisdictions, such as individual level, community level, national level, and global level. Multilevel governance and cross-scale coordination will open up opportunities for a variety of stakeholders to participate in decision-making. While potentially increasing the capacity of governance, the cross-scale and multilevel approaches may face a difficulty in policy coordination created by the plurality of stakeholders and be attended with organizational complexity. This article will examine the potential of subnational participation to make a policy choice, mediated by local governments, to be congruent with global strategies and national mandates in a consistent way. To this end, it will bring a new perspective to Kitakyushu City's experience in Japan as a heuristic test case study. My claim is that subnational actors occupy a strategic position to straddle the division between state and society, between the center and the periphery, and between the domestic and the foreign so they can act as an intermediate agent in reconnecting local action with national policy and turning global strategies into local action for problem solving.     

Japanese women in grassroots politics: building a gender-equal society from the bottom up

Abstract

The 1979 UN Convention on the Elimination of all Forms of Discrimination against Women highlights the importance of equal participation of women in public life. Since the early 1960s, women in Japan have voted in elections at significantly higher rates than men. However, Japanese women's equal participation in policy formulation and decision making lags far behind major democracies. Gender equality is stated under the Japanese Constitution, but social practices are far from equal. There are no legal constraints on Japanese women's right to candidacy for public office, but they are far underrepresented in local and national elected assemblies. In 1999 an important landmark in the substantial progress towards gender equality took place when the Japanese government, for the first time, legally denounced the stereotyped division of roles on the basis of gender and described men and women as equal partners. An unprecedented amount of legislation, together with policy changes and organizational reform at the national level were introduced from this state-led initiation. In the same year, women's grassroots groups were rapidly moving beyond the reach of policy, organizational, and legal changes; they successfully conducted a major nationwide campaign for ‘More Women to Assemblies¡’ and increased the number of elected women representatives at the local level at an unprecedented rate. The purpose of this article is to assess the potential of increased women's political voices in Japan, which can be seen as an alternative way of solving the problems of political disengagement in the male-dominated representative democracy. To this end, the article examines the course of watershed events in 1999 towards a gender-equal society in Japan, with special emphasis on the importance of grassroots missions in eliminating barriers to Japanese women's political participation.     

Quantitative analysis of tropane alkaloids in biological materials by gas chromatography-mass spectrometry

A simple and rapid method for quantitation of tropane alkaloids in biological materials has been developed using an Extrelut column with gas chromatography-mass spectrometry (GC-MS). Biological materials (serum and urine) were mixed with a borate buffer and then applied to an Extrelut column. The adsorbed tropane alkaloids were eluted with dichloromethane before a GC-MS analysis. Atropine-d(3) was used as an internal standard. The extracted tropane alkaloids were converted to trimethylsilyl derivatives prior to GC analysis, to improve the instability of tropane alkaloids from heating and the property of them for a GC column. The recoveries of the compounds, which had been spiked to biological materials, were more than 80%. The GC separation of the derivatives from endogenous impurities was generally satisfactory with the use of a semi-polar capillary column. Tropane alkaloids showed excellent linearity in the range of 10-5000 ng/ml and the limit of detection was 5.0 ng/ml for biological materials. The present method is simple and more rapid than those previously reported, and was applied to a poisoning case. It is useful for the routine analysis of tropane alkaloids in cases of suspected tropane alkaloids poisoning.     

An autopsy case of combined drug intoxication involving verapamil,metoprolol and digoxin

We present here a fatal poisoning case involving verapamil, metoprolol and digoxin. A 39-year-old male was found dead in his room, and a lot of empty packets of prescribed drugs were found near the corpse. The blood concentrations of verapamil, metoprolol and digoxin were 9.2 microg/ml, 3.6 microg/ml and 3.2 ng/ml, respectively. The cause of death was given as cardiac failure, hypotension and bradycardia due to a mixed drug overdose of verapamil, metoprolol and digoxin, based on the results of the autopsy and toxicological examination. We speculate that the toxicity of verapamil is potentiated by drug interaction with metoprolol and digoxin.     

A Retrospective View of the Heisei Economy

The Nakasone Yasuhiro Peace Institute (formerly Institute for International Policy Studies) marks its 30th anniversary this year in June 2018. The three decades that the Institute has existed coincide almost perfectly with the length of the Heisei period, as the fact that this is Heisei year 30 indicates. Therefore, in the present article, “Heisei economy” will be the term used in this review of developments in the Japanese economy over the past three decades.