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C. Robino S. Inturri A. Piccinini C. Torre 《Forensic Science International: Genetics Supplement Series》2008,1(1):160-161
Typing of X-chromosomal short tandem repeat (STR) loci in a deficiency paternity case revealed a single Mendelian incompatibility between a female child and her putative grandmother, consisting of an opposite homozygosity at locus DXS8378. The presence of a null allele due to a primer binding site mutation on the child's paternally inherited X chromosome was confirmed by amplification with newly designed DXS8378 external primers. Sequencing analysis showed a point mutation (C > T transition at position 168, according to GenBank accession G08098) in the binding site of the original DXS8378 reverse primer. 相似文献
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Population: A total of 184 healthy unrelated individuals (70 females and 114 males), autochthonous from Santa Catarina, Brazil. 相似文献
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汉族人群DXS9898基因座的遗传多态性 总被引:3,自引:0,他引:3
目的研究汉族群体DXS9898基因座的遗传多态性,为法科学应用提供基础数据。方法应用PCR及PAG电泳技术,对成都地区汉族群体199名女性无关个体及97名男性无关个体进行群体遗传学调查。结果共检出6个等位基因,片段大小为189~214bp,其基因型分布符合Hardy-Weinberg平衡。家系调查证实等位基因的传递遵循孟德尔遗传规律。女性样本杂合度为0.5930;男、女性样本个人识别能力(Dp)分别为0.5667、0.9420;父-母-女三联体鉴定的非父排除率(PE)为0.5862。结论DXS9898基因座在法科学个人识别及女性小孩的亲权鉴定中具有较高的实用价值。 相似文献
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POPULATION: One hundred unrelated females and 100 unrelated males, autochthonous, healthy, from the North of Portugal. 相似文献
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J.J. Builes R.E. Martinez C. Espinal M.L. Bravo 《Forensic Science International: Genetics Supplement Series》2008,1(1):140-141
The X-linked short tandem repeats (STR) markers have proven to be very useful tools for paternity testing when the disputed child is female. The aim of this study was to describe the polymorphism of three X-chromosomal STR loci (DXS6797, DXS6800 and HPRTB) in an Antioquian (Colombian) population sample. PCR products were separated in 4% acrylamide-bis-acrylamide denaturing gels followed by silver staining. Allele size determination and genotyping were performed according to recommendations of the DNA Commission of the International Society of Forensic Genetic using the allelic ladder manufactured at home and based on DNA controls including K562 and 9947A (Promega). Gene frequencies were calculated using ARLEQUIN version 3.11. Population genetic data were obtained by analyzing 127-400 unrelated males and 135 unrelated females from Antioquian (Colombian) population. Distribution of the allele frequencies of these systems for Antioquia population is similar to the European populations. 相似文献
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R.E. Martinez M.L. Bravo S.I. Polo L. Gusmão 《Forensic Science International: Genetics Supplement Series》2008,1(1):153-154
The X linked short tandem repeats (STR) markers have proven to be very useful tools for paternity testing when the disputed child is female. The purpose of this study was to describe the genetic polymorphism of four X-chromosomal STR loci (DXS6797, DXS6800, HPRTB and GATA172D05) in a Peruvian population sample and evaluate their efficiency in forensic practice and paternity testing. 相似文献
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Iva Gomes Mechthild Prinz Erik Bieschke Angel Carracedo 《Forensic Science International: Genetics Supplement Series》2008,1(1):147-149
Sequence variation for the X chromosome short tandem repeats (X-STRs) DXS9898, DXS6789 and GATA172D05 was studied in two major population groups, namely Caucasians and Africans. DXS6789 revealed two different subtype sequence polymorphisms: for shorter alleles, with less than 17 repeats, results showed a simple composition with the following structure: (TATG)m-(TATC)n. For longer alleles, a constant TATC insertion was observed at the beginning of the variable repeat unit. Additionally, alleles identical in size revealed structural variations regarding the TATG/TATC proportion. Africans showed a higher intra-allelic variation at this locus than the Caucasian population group. For all three loci, DXS9898, DXS6789 and GATA172D05, no unique structure was found among Africans and Caucasians. 相似文献
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