合成大麻素类新精神活性物质4F-MDMB-BICA的检测

目的建立基于红外光谱(fourier transform infrared,FT-IR)、气相色谱-质谱联用(gas chromatographymass spectrometry,GC-MS)、高分辩质谱(high resolution mass spectrometer,HRMS)和核磁共振波谱(nuclear magnetic resonance spectroscopy,NMR)多技术联用鉴定可疑未知物的方法。方法样品分别用FT-IR、GC-MS、HRMS(溶剂为甲醇)及NMR(溶剂为氘代甲醇)检测。结果GC-MS测得样品中主要组分的质谱特征离子m/z分别为218(基峰)、362、306、274、246、144、116,HRMS实测的精确质量数M+H]+为363.20774,经FT-IR、GC-MS和HRMS数据分析,推断未知样品为一种新的合成大麻素类新精神活性物质4F-MDMB-BICA,并用1H NMR对其结构进行确证。结论建立的多技术联合鉴定方法能用于未知样品中4F-MDMB-BICA的鉴定。该方法快速、方便、准确、可靠、实用,能够对今后涉及此类物质的案件检测鉴定提供参考依据。

Detection of 4F-MDMB-BICA,a new synthetic cannabinoid psychoactive substance

Objective To establish a method based on FT-IR,GC-MS,HRMS and NMR,so as to identify new psychoactive substance of Synthetic cannabinoids.Method The samples were detected by FT-IR,GC-MS,HRMS(solvent is methanol)and NMR(solvent is deuterated methanol).Results The characteristic ions(m/z)of the main components in the sample was 218(base peak),362、306、274、246、144、116 respectively by GC-MS.The accurate mass of protonated molecular ion(M+H]+)measureed by HRMS was 363.20774.The data analysis of FT-IR,GC-MS and HRMS showed that the unknown sample was a new synthetic cannabinoid psychoactive substance,4F-MDMBBICA.Conclusion The established method can be used to identify 4 F-MDMB-BICA in unknown samples.The method is fast,convenient,reliable and practical,which can provide reference for the detection and identification of cases involving such substances in the future.