过敏性休克诊断的法医学研究进展

过敏性休克的诊断一直是法医学死亡原因鉴定工作的重点和难点之一。因为尸检中缺乏特异性的病理学改变,案情调查时过敏性休克的发生过程和病情进展及既往过敏史不详,且患者常患有冠心病、肺炎、哮喘、皮肤过敏等疾病,死亡时间长导致血清过敏指标的降解等因素,是检案工作中常常遇到的问题。本文拟对过敏性休克的鉴定现状和诊断指标,包括病理形态学改变、特殊染色、免疫组化、血清学检查等实验方法在过敏性休克中的应用进行综述,以期能为过敏性休克的诊断和研究提供参考。

Advancement on the diagnosis of anaphylactic shock in forensic medicine

It is still an important and hard work to diagnose anaphylactic shock in forensic practice. However, no breakthrough progresses in the diagnosis of anaphylactic shock and relevant research have been made so far due to the problems we used to meet in actual postmortem examination ,which are short of specific pathological changes in autopsy, the condition progress of patients who occur anaphylactic shock and history of allergy. Furthermore, patients suffer from diseases such as coronary heart disease, pneumonia, asthma, skin irritation, etc, and blood serum allergy biomarkers degrade after hemolysis on account of a long time from death to autopsy ,which are also the difficulties we have to cope with. The aim of this review is to focus on present situation and diagnostic index of anaphylactic shock including the pathological changes and some experimental methods such as special stain, immunohistochemical and serological test to provide reference for diagnosis and study of anaphylactic shock.