针刺心经对急性心肌缺血模型大鼠血流动力学指标的影响

目的 观察针刺心经对急性心肌缺血模型大鼠心电图和血流动力学指标的影响，探讨针刺抗急性心肌缺血的效应。方法 将SD大鼠随机分为伪手术组、模型组、针刺心经组、非经非穴组，每组各10只，通过冠状动脉左前降支结扎法复制大鼠急性心肌缺血模型，针刺心经组取“神门（HT7）—通里（HT5）”经脉段，非经非穴组取大鼠臀部非经穴刺激点，各刺入3根1寸毫针，间距约2 mm；电针每次30 min，每天1次，连续3次。观察比较各组大鼠血流动力学指标心率（heart rate,HR）、平均动脉压（mean arterial pressure，MAP）和心率收缩压乘积（rate pressure product，RPP）。结果 末次针刺后即刻（0 min），与伪手术组比较，模型组大鼠HR显著增加，MAP、RPP显著下降 （P<0.01）；与模型组、非经非穴组比较，针刺心经组大鼠HR显著下降，MAP、RPP显著上升（P<0.05，或P<0.01）； 末次针刺后10、20、30 min，与模型组、非经非穴组比较，针刺心经组大鼠HR显著下降，MAP、RPP显著升高 （P<0.01）。结论 针刺心经可逆转急性心肌缺血大鼠心电图和血流动力学指标的异常变化，具有改善急性心肌缺血的确切效应。

Effects of Acupuncture at Heart Channel on Electrocardiogram and Hemodynamic Parameters in Rat Model of Acute Myocardial Ischemia

Objective To observe the effects of acupuncture at the heart channel on the electrocardiogram (ECG) and hemodynamic parameters in the rat model of acute myocardial ischemia and to investigate the efficacy of acupuncture in the treatment of acute myocardial ischemia. Methods Sprague-Dawley rats were divided into sham-operated group, model group, acupuncture group (treated by acupuncture at the heart channel), and non-acupoint group, with 10 rats in each group. A rat model of acute myocardial ischemia was induced by ligation of the left anterior descending coronary artery. Electroacupuncture was performed at Shenmen (HT7)-Tongli (HT5) points of the heart channel in the acupuncture group, but at non-acupoints in the hip in the non-acupoint group; for each rat, electroacupuncture was performed using three filiform needles (length=1/30 m, spacing=2 mm) three times (once daily, 30 min each time). These groups were compared in terms of heart rate, mean arterial pressure (MAP), and rate pressure product (RPP). Results At 0 min after electroacupuncture, the model group had a significantly increased heart rate and significantly reduced MAP and RPP compared with the sham-operated group (P<0.01); the acupuncture group had a significantly reduced heart rate and significantly increased MAP and RPP compared with the model group and non-acupoint group (P<0.05 or P<0.01). At 10, 20, and 30 min after electroacupuncture, the acupuncture group had a significantly reduced heart rate and significantly increased MAP and RPP compared with the model group and non-acupoint group (P<0.01). Conclusion Acupuncture at the heart channel can reverse abnormal ECG and hemodynamic parameters in rats with acute myocardial ischemia and has good efficacy in the treatment of this disease.