化肝煎治疗难治性胃食管反流病临床观察

目的 观察化肝煎联合兰索拉唑治疗难治性胃食管反流病（gastroesophageal reflux disease，GERD）的临床疗效。方法 将66例难治性GERD患者随机分为治疗组和对照组，每组33例。对照组采用兰索拉唑口服，治疗组在对照组的基础上加化肝煎口服。观察两组治疗前、治疗4周后中医证候积分、胃食管反流病问卷（gastroesophageal reflux disease questionnaire，GERD-Q）积分的变化，并比较两组临床疗效。结果 与治疗前比较，两组患者治疗后中医证候积分、GERD-Q积分均显著减少（P＜0.05）；治疗组患者中医证候积分、GERD-Q积分减少程度均明显大于对照组（P＜0.05）。两组中医证候疗效比较，差异有统计学意义（P＜0.05）。结论 化肝煎联合兰索拉唑治疗难治性GERD疗效确切，不良反应少。

Clinical Effect of Huagan Decoction in Treatment of Refractory Gastroesophageal Reflux Disease

Objective To investigate the clinical effect of Huagan Decoction combined with lansoprazole in the treatment of refractory gastroesophageal reflux disease (GERD). Methods A total of 66 patients with refractory GERD were randomly divided into treatment group and control group, with 33 patients in each group. The patients in the control group were given oral lansoprazole, and those in the treatment group were given oral Huagan Decoction in addition to the treatment in the control group. The two groups were observed in terms of traditional Chinese medicine (TCM) syndrome score and Gastroesophageal Reflux Disease Questionnaire (GERD-Q) score before treatment and after 4 weeks of treatment, and clinical outcome was compared between the two groups. Results Both groups had significant reductions in TCM syndrome score and GERD-Q score after treatment (P<0.05), and the treatment group had significantly greater reductions than the control group (P<0.05). There was a significant difference in the treatment outcome of TCM syndrome between the two groups (P<0.05). Conclusion Huagan Decoction combined with lansoprazole has a good clinical effect in the treatment of refractory GERD, with few adverse events.