| 人类线粒体DNA的异质型 |
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| 引用本文： | 赵兴春,姜成涛,靳大庆,郑秀芬.人类线粒体DNA的异质型[J].中国法医学杂志,2001(Z1). |
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| 作者姓名： | 赵兴春 姜成涛 靳大庆 郑秀芬 |
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| 作者单位： | 公安部物证鉴定中心，公安部物证鉴定中心，中国人民公安大学，公安部物证鉴定中心 北京 100038，北京 100038，北京 100038，北京 100038 |
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| 摘 要： | 研究中国人群中线粒体 D 环区不同组织间的差别,用 PCR-测序方法对53个无关个体的毛发与血液样本进行线粒体 DNA 高变区 HVⅠ进行测序分析,通过377测序仪检测,发现1例个体中血液与毛发样本线粒体 HV Ⅰ区15997～16401间存在序列差异。在16235碱基处,毛发样本表现为 T,血液样本为 C/T。结果显示中国人群同一个体不同组织存在线粒体序列差异。
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| 关 键 词： | 法庭科学 线粒体 DNA 异质型 测序 |
A study of heteroplasmy of mtDNA in Chinese |
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| ZHAO Xingchun JIANG Chengtao JIN Daqing The Institute of Forensic Science,Beijing.A study of heteroplasmy of mtDNA in Chinese[J].Chinese Journal of Forensic Medicine,2001(Z1). |
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| Authors: | ZHAO Xingchun JIANG Chengtao JIN Daqing The Institute of Forensic Science Beijing |
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| Institution: | ZHAO Xingchun JIANG Chengtao JIN Daqing The Institute of Forensic Science,Beijing 100038 |
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| Abstract: | To study whether there is sequence difference of mtDNA D-loop region in different tissues from the same Chinese individual.The blood and the hair samples from 53 unrelated Chinese individuals were tested by using PCR based mtDNA sequencing with PE automated sequencer.It was found that the sequences of mtDNA HV1 15997-16401 region of blood and the hair from the same Chinese individual was different.There was a single base difference between them.The base at 16235 of the hair was T,while of the blood C/T.The results showed that there was sequence difference of mtDNA in different tissues from the same Chinese individual. |
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| Keywords: | Forensic sciences mitochobndrial DNA(mtDNA) Heteroplasmy Sequencing |
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