| 甲基苯丙胺对映异构体两种衍生化方法的比较分析 |
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| 引用本文： | 张建新,张大明,韩旭光,乔静,杨士云,辛国斌.甲基苯丙胺对映异构体两种衍生化方法的比较分析[J].中国法医学杂志,2009,24(5):289-292. |
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| 作者姓名： | 张建新 张大明 韩旭光 乔静 杨士云 辛国斌 |
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| 作者单位： | 1. 北京市公安局法医检验鉴定中心,北京,100192
2. 公安部缉毒局,北京,100741 |
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| 基金项目： | 国家科技部十一五攻关资助项目 |
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| 摘 要： | 目的建立甲基苯丙胺毒品的对映异构体分析的优化方法。方法按文献方法用（S）-（＋）-a-甲氧基-a-（三氟甲基）苯基乙酰氯（MTPACl）对甲基苯丙胺直接衍生化和在碱性条件下用有机溶剂萃取后再用MTPACl衍生化（对文献方法优化）,分别对其衍生物采用全扫描形式进行GC-MS分析,比较其结果。结果优化方法的检测限低,峰型好,副反应少。文献方法的检测限是0.1ng,优化方法的检测限是0.001 6ng。结论优化方法用于甲基苯丙胺的对映体特征分析,结果更准确,实用性更强。
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| 关 键 词： | 法医毒物分析 甲基苯丙胺 GC-MS 对映异构体 |
Comparison of two derivatization methods for enantiomer profiling of methamphetamine |
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| ZHANG Jianxin,ZHANG Daming,HAN Xuguang,QIAO Jing,YANG Shiyun,XIN Guobin.Comparison of two derivatization methods for enantiomer profiling of methamphetamine[J].Chinese Journal of Forensic Medicine,2009,24(5):289-292. |
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| Authors: | ZHANG Jianxin ZHANG Daming HAN Xuguang QIAO Jing YANG Shiyun XIN Guobin |
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| Institution: | (ZHANG Jianxin1,ZHANG Daming1,HAN Xuguang2,QIAO Jing1,YANG Shiyun1,XIN Guobin1/1.Forensic Medical Examination Center of Beijing Public Security Bureau,Beijing 100192,China,2.The Ministry of Public Security of the People,Republic of China,Beijing 100741,China) |
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| Abstract: | Objective A procedure to analyze enantiomer profiling of methamphetamine was optimized.Methods According to the procedure optimized by us,methamphetamine samples were extracted by organic solvent from alkali aqueous solution and then derivatized with(S)-(+)-MTPACl).To another procedure introduced in a literature,methamphetamine isomers were directly derivatized with(S)-(+)-a-methoxy-a-(trifluoromethyl)phenylacetyl chloride((S)-(+)-MTPACl).The both derivatives were analyzed by GC-MS in full scan monitoring m... |
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| Keywords: | GC-MS |
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