| GC/MS法测定血液中的米氮平 |
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| 引用本文： | 乔静,杨士云,杨继锋.GC/MS法测定血液中的米氮平[J].中国法医学杂志,2012,27(5):394-395,398. |
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| 作者姓名： | 乔静 杨士云 杨继锋 |
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| 作者单位： | 北京市公安局法医检验鉴定中心,北京,100192 |
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| 摘 要： | 目的采用液液提取-GC/MS法检测血液中米氮平。方法用0.1mol/L NaOH溶液调节血液pH值为8～9,以二氯甲烷∶环己烷(4∶6)混合溶剂作为提取溶剂,液液提取法提取血液中米氮平,外标法气相色谱/质谱联用仪定性定量分析。在2mL血中分别添加标准米氮平1、0.5、0.1μg,进行回收率测定。结果血液中添加米氮平的平均回收率为91.5%,方法的工作曲线为Y=1E+06X-16206,相关系数r=0.999 7,线性范围0.5～10μg/mL,最小检出限0.1μg/mL(S/N=46)。结论本文方法操作简便,适合于血液中米氮平的定性、定量分析,可在实际捡案中选择使用。
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| 关 键 词： | 法医毒物分析 血液 米氮平 液液提取 GC/MS分析 |
Analysis of mirtazapine in whole blood by GC/MS |
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| Qiao Jing
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Yang Shiyun
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Yang Jifeng.Analysis of mirtazapine in whole blood by GC/MS[J].Chinese Journal of Forensic Medicine,2012,27(5):394-395,398. |
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| Authors: | Qiao Jing Yang Shiyun Yang Jifeng |
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| Institution: | /The Forensic Medical Examination Center,Beijing Breau of Public Security,Beijing 100192,China) |
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| Abstract: | Objective To develop liquid-liquid extraction and GC/MS method for the determination of Mirtazapine.Methods Mirtazapine were extracted from whole blood using dichlormethane:cyclohexane(4∶ 6),pH value is adjusted as 8~9 by 0.1mol/L NaOH,and detected with external standard by GC/MS.Results The recovery of Mirtazapine was 91.5%,The correlation coefficient of linear curve was 0.999 7 with in concentration rang 0.5~10μg/mL,The limit of qualification was 0.1μg/mL(S/N=46).Conclusion The method was simple and rapid for qualitative and quantitative analysis of mirtazapine in whole blood. |
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| Keywords: | forensic toxicological analysis blood mirtazapine liquid-liquid extraction GC/MS |
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