新型毒品5-甲氧基-α-甲基色胺油状物的GC-MS定性检验

目的通过分析未知检材样本提取后的质谱碎裂峰,建立了5-甲氧基-α-甲基色胺(5-MeO-AMT)的气相色谱-质谱(GC-MS)定性分析方法,并阐述其在EI离子源轰击下的分子裂解机制。方法未知样品油状物用氢氧化钠溶液溶解后加入适量乙酸乙酯,充分振荡后吸取上清液采用气相色谱-质谱(GC-MS)检测。结果测得未知组分(RT=12.754min)的质谱特征碎片峰(m/z)信息为161.1(基峰)、204.2、146.1、130.1、117.1和89.0。经与NIST谱库和DEA报告质谱图比对,确定为5-MeO-AMT;通过查阅文献资料,对上述质谱特征碎片峰的产生机制进行了推断。结论该方法操作简单、结论可靠,可用于5-MeO-AMT的检验。

GC-MS Qualitative Identifi cation of Oil-formulized 5-Methoxy-alpha-Methyltryptamine,a New-type Drug

Objective To establish a gas chromatography-mass spectrometry(GC-MS)method for qualitative analysis of 5-methoxy-α-methyltryptamine(5-MeO-AMT)from a sample(seized of a case)detected through effective extraction and the followed GC-MS determination,together with a postulation on the mechanism of fragmentation from such a chemical molecule upon electron impacting(EI).Methods One case-seized,ingredient-unknown and oily substance,suspected of harboring 5-MeO-AMT,was aqueously dissolved into sodium hydroxide solution,afterwards added with ethyl acetate to extract the purposed chemical.Through oscillation and centrifugation,the supernatant was transferred to subject to GC-MS analysis.Results One unknown component(RT=12.754min)was detected,appearing its characteristic fragment ion peaks at m/z 161.1(base peak),204.2,146.1,130.1,117.1 and 89.0.Matched well to the records of characteristic fragment ion peaks from Nist library and DEA report,the chemical was identified as 5-Methoxy-alpha-methyltryptamine in the tested oily substance.Furthermore,the postulated pathway of EI-induced fragmentation of 5-MeO-AMT was described with reference to relevant literatures.Conclusion A robust and reliable GC-MS approach was developed for 5-MeO-AMT to be extracted and identified,capable of being applied into relevant cases.