| 北京地区汉族人群6个STR基因座的遗传多态性 |
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| 引用本文： | 邹凯南,欧元,姜伯玮,焦志,连昌舟,姜成涛,赵兴春,叶健.北京地区汉族人群6个STR基因座的遗传多态性[J].刑事技术,2009(1):19-22. |
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| 作者姓名： | 邹凯南 欧元 姜伯玮 焦志 连昌舟 姜成涛 赵兴春 叶健 |
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| 作者单位： | 1. 中国人民公安大学,北京,100038
2. 公安部物证鉴定中心,北京,100038 |
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| 摘 要： | 目的对北京地区汉族人群遗传数据进行调查研究。方法利用PCR自动化检测技术检测中国北京地区汉族人群D1S1656，D10S2325，D11S2368，D12S391，D14S1434及GATA198B05共6个STR基因座的遗传多态性，获得6个STR基因座的群体遗传学数据，评价其法医学应用价值。结果6个STR基因座的个体鉴别力（Discrimination power，DP）在0．9777-0．8769之间，多态性信息含量（Polymorphism information content，PIC）在0．6867-0．8801之间，杂合度（Heterozygosity，H）在0．7219～O．8684之间，非父排除率（Probability of paternity exclusion，PE）在0．4456-0．6793之间，累积个体鉴别力为0．99999997，累积非父排除率为0．995765192。结论6个STR基因座等位基因频率分布均匀，多态性高，适用于法医学亲子鉴定及个人识别，可作为现有基因座的补充。
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| 关 键 词： | 法庭科学 短串联重复序列 遗传多态性 聚合酶链式反应 |
Genetic Polymorphism of D1S1656, D10S2325, D11S2368, D12S391, D14S1434 and GATA198B05 in Chinese HanPopulation of Beijing |
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| Institution: | ZOU Kai-Nan, OU Yuan,JIANG Bo-Wei, et al. (Chinese People＇s Public Security University, Beijing 100038,China) |
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| Abstract: | To investigate the genetic polymorphism of DIS1656, D10S2325, DllS2368, D12S391, D14S1434, GATA198B05 in Chinese Han population of Beijing, PCR method was used. All allele frequencies, heterozygosity （H）, discrimination power（DP）, exclusion of paternity probability（PE） and polymorphism information content（PIC） were calculated. The DP is at 0. 9777-0. 8769 , PIC is at 0. 6867-0. 8801, H is at 0. 7219-0. 8684, PE is at 0. 4456-0. 6793. According to the results obtained in this study, it is suggested that D1S1656 ,D10S2325 ,DllS2368, D12S391 ,D14S1434 and GATA198B05 were useful genetic markers for individual identification and paternity testing in forensic science and they were complementary to general loci. |
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| Keywords: | Chinese Han population PCR STR genetic pdymerphism |
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