自制海洛因标准品在常用有机溶剂中稳定性研究

目的 研发海洛因标准品及优化分析方法,以对云南缴获海洛因样本提纯制备成的自制海洛因对照品在常用有机溶剂中的稳定性进一步研究.方法 采用内标及GC、GC/MS方法,通过对提纯制备的海洛因在5种有机溶剂中冷藏保存后含量的变化,观察海洛因在常用有机溶剂中的稳定性.结果 乙醇、三氯甲烷及乙腈为溶剂的自制海洛因对照品储备液,保存30天时间范围内海洛因含量未发生明显变化;以丙酮作为溶剂的自制海洛因对照品储备液,在7至30天时间范围内,海洛因含量明显升高;以甲醇作为溶剂的自制海洛因对照品储备液,在0小时至30天时间范围内,海洛因含量一直呈明显的下降趋势.结论 乙醇、三氯甲烷及乙腈可以作为海洛因样品储备液溶剂使用,丙酮、甲醇不适合作为海洛因样品储备液溶剂使用.

The study on stability of heroin standard in organic solvents

Objective To explore the stability of heroin in various organic solvents. Methods An internal standard method of gas chromatography （GC） was employed to analyze the content of heroin （prepared in our laboratory） in organic solvents. The content variation of heroin in five kinds of organic solvents kept in refrigeration was continuous monitored at different time periods. Results The results demonstrated that the heroin content in ethanol, trichloromethane and acetonitrile did not change significantly within 30 days. However, the heroin content increased significantly from 7 to 30 days when acetone was used as solvent and the heroin content in methanol showed an obvious decrease trend from 0 h to 30 days. Conclusion Ethanol, trichloromethane and acetonitrile can be selected as the solvent of heroin, but acetone and methanol are not suitable as solvent of heroin.