| 快速溶剂萃取-气相色谱/质谱法分析血液中的4种滥用药物 |
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| 引用本文： | 李文海,蔺大伟,孙红雷,木台力甫·麦麦提吐逊,王磊.快速溶剂萃取-气相色谱/质谱法分析血液中的4种滥用药物[J].刑事技术,2014(3):9-11. |
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| 作者姓名： | 李文海 蔺大伟 孙红雷 木台力甫·麦麦提吐逊 王磊 |
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| 作者单位： | [1] 山东省泰安市公安局刑警支队,271000 [2] 新疆喀什地区公安处刑侦支队,844000 |
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| 摘 要： | 目的 建立生物检材血液中滥用药物的快速溶剂萃取（ASE）方法.方法 通过优化快速溶剂萃取各参数,提取血液中的滥用药物进行GC/MS定性定量分析.结果 血液中美沙酮、可卡因、蒂巴因、海洛因4种滥用药物的平均回收率在87.8％～97.5％之间,滥用药物在0.4μg/mL～4.0μg/mL的浓度范围内线性良好.结论 该方法具有操作简便快捷,回收率高、重现性好等特点,可广泛应用于生物检材血液中滥用药物的检验鉴定.
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| 关 键 词： | 毒物分析 快速溶剂萃取 气相色谱 质谱联用仪 滥用药物 |
Determination of four drugs in blood by accelerated solvent extraction coupled with GC/MS |
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| Institution: | LI Wen-hai, LIN Da-wei, SUN Hong-lei, et al (Public Security Bureau of Taian City, Shandong 271000,China) |
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| Abstract: | Objective To develop an analysis method for determining drugs from blood. Methods Methadone, cocaine, thebaine and heroin in blood were extracted by accelerated solvent extraction（ASE） and analyzed with GC/MS. Results The recoveries of four drugs were ranged from 87.8% to 97.5 %. A good linear relationship was obtained at the concentration range of 0. 4μg/mL ～4. 0μg/mL. Conclusion The method has high recovery, good repeatability and easy to operation. It can be used to the casework. |
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| Keywords: | forensic toxicology accelerated solvent extraction GC/MS drug abuse |
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