头孢噻呋钠-壳聚糖纳米粒的制备及相关性质的研究

为了延长头孢噻呋钠的作用时间,采用离子交联法制备头孢噻呋钠-壳聚糖纳米粒,研究其形态、粒径、载药量、包封率和体外释药特性。结果显示,经优化工艺所得的纳米粒形态规整,近圆形,平均粒径为179.4±39.5nm,平均包封率为84.31%±2.53%,平均载药量为6.69%±0.18%。体外释放试验表明,原料药在放入释放介质后第4小时释放率达到90%以上,而纳米粒在此时药物仅释放60%。结果表明,该纳米粒制备工艺可行,对头孢噻呋钠具有明显的缓释效果。     

Cascading Bias of Initial Exposure to Information at the Crime Scene to the Subsequent Evaluation of Skeletal Remains,

Thirty‐eight participants took part in a study that investigated the potential cascading effects of initial exposure to extraneous context upon subsequent decision‐making. Participants investigated a mock crime scene, which included the excavation of clandestine burials that had a male skeletal cast dressed either in female or gender neutral clothing. This was followed by a forensic anthropological assessment of the skeletal remains, with a control group assessing the same male skeletal cast without any clothing context. The results indicated that the sex assessment was highly dependent upon the context in which participants were exposed to prior to the analysis. This was especially noticeable in the female clothing context where only one participant determined the male skeletal cast to be male. The results demonstrate the importance of understanding the role of context in forensic anthropology at an early stage of an investigation and its potential cascading effect on subsequent assessments.     

Evaluation of the use of pharmacological treatment with prisoners experiencing high levels of hypersexual disorder

This paper presents an evaluation of the impact of pharmacological treatment in reducing hypersexual disorder in adult males who have been incarcerated following conviction for a sexual offence. The evaluation compares two types of pharmacological treatment, one of which is part of the current NICE guidance for treatment of hypersexuality (Antiandrogens), whilst the other type (SSRIs) is off-label use in the UK for hypersexuality. The participant pool comprised 127 adult male prisoners serving sentences for sexual offences in a UK prison. Participants had been voluntarily referred for pharmacological treatment to manage hypersexual disorder. The results demonstrated a significant reduction of hypersexual disorder pre- and post-medication and contribute to the evidence base for the use of pharmacological treatment with individuals for whom hypersexual disorder may be a salient factor in their offending. Limitations of the current research are discussed.     

The suitability of visual taphonomic methods for digital photographs: An experimental approach with pig carcasses in a tropical climate

In the context of increased scrutiny of the methods in forensic sciences, it is essential to ensure that the approaches used in forensic taphonomy to measure decomposition and estimate the postmortem interval are underpinned by robust evidence-based data. Digital photographs are an important source of documentation in forensic taphonomic investigations but the suitability of the current approaches for photographs, rather than real-time remains, is poorly studied which can undermine accurate forensic conclusions. The present study aimed to investigate the suitability of 2D colour digital photographs for evaluating decomposition of exposed human analogues (Sus scrofa domesticus) in a tropical savanna environment (Hawaii), using two published scoring methods; Megyesi et al., 2005 and Keough et al., 2017. It was found that there were significant differences between the real-time and photograph decomposition scores when the Megyesi et al. method was used. However, the Keough et al. method applied to photographs reflected real-time decomposition more closely and thus appears more suitable to evaluate pig decomposition from 2D photographs. The findings indicate that the type of scoring method used has a significant impact on the ability to accurately evaluate the decomposition of exposed pig carcasses from photographs. It was further identified that photographic taphonomic analysis can reach high inter-observer reproducibility. These novel findings are of significant importance for the forensic sciences as they highlight the potential for high quality photograph coverage to provide useful complementary information for the forensic taphonomic investigation. New recommendations to develop robust transparent approaches adapted to photographs in forensic taphonomy are suggested based on these findings.     

An effective pedagogy for child welfare education

ABSTRACT

Preparing social workers for child welfare practice with the complexly traumatized children now in the system has created the need for schools of social work to integrate trauma content into the curriculum. This article presents findings of an evaluation of a child welfare course designed to prepare MSW level trauma-informed child welfare practitioners. Findings indicate that students in 29 schools of social work not only significantly increased their confidence in working with traumatized children and families but also are significantly more prepared to work toward these three child welfare goals of safety, permanency, and well-being.     

Enhancing judicial skills in domestic violence cases: the development,implementation, and preliminary evaluation of a model US programme

ABSTRACT

The overwhelming number and complexity of domestic violence cases in criminal and family courts has resulted in the development of education programmes to assist judges. There is limited research on judicial education in this area. This paper reviews one such initiative entitled ‘Enhancing Judicial Skills in Domestic Violence Cases’ (EJS) that has been developed and implemented over the last 20 years by the National Judicial Institute on Domestic Violence, a partnership of the US Department of Justice Office on Violence Against Women, National Council of Juvenile and Family Court Judges and Futures Without Violence. We present findings of a preliminary evaluation of the programme based on the self-reports of 480 judges who had taken the four-day workshop between 2006 and 2010. Overall, judges reported the programme to be engaging and effective. At a six-month follow‐up, most of the judges identified specific benefits and behavior changes in the areas of access to justice, judicial leadership, victim safety, and abuser accountability as a result of participating in the programme. Critical issues in judicial education are highlighted based on the authors’ experiences in the development and implementation of this programme.     

陕西西部大开发税收政策执行评价及调整方向

在上一轮西部大开发政策的支持下,陕西经济社会发展取得了巨大成就。新一轮西部大开发的税收优惠政策虽已明确,但对于陕西来说,这些政策还应着重在支持陕西发展优势,支持陕西经济发展薄弱环节的税收优惠政策上,以及在宏观层面支持陕西经济社会发展的税收政策等方面予以完善。     

二乙酰吗啡盐酸盐标准物质的研制（2）-定值和不确定度评定

目的对研制的二乙酰吗啡盐酸盐标准物质进行定值,并评定定值结果的不确定度。方法采用定量核磁共振法和质量平衡法进行定值;采用液质联用法用于有机物杂质的定性分析,采用电感耦合等离子质谱法、离子色谱法、顶空-气质联用法和卡尔费休滴定法测定无机阳离子、阴离子、挥发性有机溶剂残留和水分等杂质的含量。结果定量核磁共振法的纯度为95．6％,不确定度为0．13％;质量平衡法的纯度为95．3％,不确定度为0．93%。结论二乙酰吗啡盐酸盐标准物质的纯度值为95．6％,扩展不确定度为1．2％（k=2）。     

浅谈食品安全风险评估机构独立运行的必要性

目前,我国风险评估机构属行政序列,其评估工作不能独立、科学的运行,导致食品安全风险预警职能无法发挥,食品安全事故频发。食品安全风险评估机构有独立运行的必要性,为实现食品安全风险评估机构独立运行,应列入人大序列进行理论探讨,以求为实践提供借鉴。     

Changing perspectives in cognitive interviewing

A study is presented which investigated aspects of a specialist method for taking evidence from witnesses known as ‘Cognitive Interviewing’. Specifically, the study sought to evaluate four techniques used in this form of interviewing, namely the Report All, Reinstate Context, Change Order, and the Change Perspectives mnemonics. The findings suggest that while none of these mnemonics significantly increased inaccuracy, all but the Change Perspectives mnemonic facilitated recall of accurate information. The findings are discussed in terms of the applied functional utility of each of the mnemonics and the Cognitive Interview procedure in general.