大鼠急性心肌缺血早期内皮素的免疫组化染色观察

目的　探讨实验性大鼠心肌缺血后内皮素在心肌组织内的表达变化。方法　运用免疫组化技术 (SABC法 ) ,对分别经过单纯缝线结扎、药物、脂质饮食预处理后结扎及假结扎处理的 5组 60只实验大鼠 ,在冠脉左前降支结扎后的不同时间点 ,观察心肌组织的内皮素表达情况。结果　阳性组各个分组的大鼠在心肌缺血早期均出现了内皮素的阳性表达 ,且经过预处理、存在慢性心肌缺血倾向的大鼠在更短的时间内出现了阳性染色 ;而假结扎对照组未见明显的阳性染色。结论　内皮素免疫组化检测可作为早期心肌缺血的病理诊断指标之一 ,并可为心性猝死 (SCD)的诊断提供形态学依据。     

冠状动脉内弹力膜缺损与冠心病猝死的关系

目的探讨冠状动脉内弹力膜(IEL)病变与冠心病猝死(SCD)的关系。方法从本单位近5年尸检案例中挑选60例病例和心脏标本,分为SCD组、对照组A和B组。每例分别在冠状动脉左前降支近段取材,常规制片,HE和双重组合特殊染色,显微镜下观察冠状动脉IEL,并用图像分析技术对特殊染色的IEL进行形态定量分析。结果60例中,SCD组(男性24例,女性6例,年龄30~83岁)的冠状动脉IEL缺失明显(缺失率=41.64%),未缺失的IEL失去原有弯曲度而变平直;对照组A(冠心病非猝死者,男性13例、女性2例,年龄41~80岁)的冠状动脉IEL缺失程度较SCD组稍轻(缺失率=30.53%);对照组B(无冠心病的其他死者,男性8例,女性7例,年龄17~54岁)的冠状动脉IEL仅有轻度缺失(缺失率=15.67%),多保持原有波浪状结构。统计学分析显示,SCD组与对照组、SCD组与对照组B、对照组A与对照组B之间IEL缺损率的差异均具有极显著性意义;SCD组与对照组A在IEL缺损率上的差异有显著性意义。结论SCD与其冠状动脉IEL缺损率的大小密切相关。     

冠状动脉粥样斑块中C-反应蛋白的免疫组化研究

目的探讨冠状动脉粥样硬化斑块中C-反应蛋白(CRP)对冠心病猝死(SCD)的诊断意义。方法从本教研室2001~2004年尸检案例中挑选68例案例资料和心脏标本,分为3组A组SCD(27例);B组冠心病非猝死者(21例);C组无明显动脉粥样硬化病变的死者(20例);应用免疫组化染色(SABC法)和图像分析技术,检测每例冠状动脉左前降支和右主支粥样硬化斑块内的CRP染色情况,并对所得数据进行统计分析。结果A组有20例CRP免疫组化染色强阳性,6例呈较强阳性,1例为弱阳性;B组中3例呈较弱阳性,11例微弱阳性,7例为阴性;C组均未见阳性反应。结论检测冠状动脉粥样硬化斑块中的CRP对SCD的死后诊断具有一定意义。     

冠心病猝死心肌肌动蛋白缺失的免疫组织化学定量研究

应用免疫组织化学LSAB法和图像处理系统，对德国慕尼黑大学法医学研究所1994年尸检冠心病猝死和对照组病例（各15例）的心肌肌动蛋白缺失情况进行定量研究。发现冠心病猝死病例心肌纤维内有明显的肌动蛋白缺失，是大小不一，多发、散在分布；对照组无或仅局限性小灶状缺失。将检测结果定量分析比较，其差异非常显著，说明重度冠状动脉粥样硬化患者是否冠心病猝死，其心肌肌动蛋白缺失的范围和程度有明显差异，冠心病猝死和对照组病例心肌肌动蛋白缺失的差异具有诊断意义，而形态定量分析能较客观准确地反映心肌纤维内肌动蛋白缺失量的变化。     

心脏神经病

目的 研究心源性猝死的病理形态学。方法 用本组建立的CCS检查法对179例心源性猝死者作常规CCS组织学检查。结果 发现8例心脏神经或神经节内有出血、炎症或肿瘤浸润,伴神经组织水肿、变性、坏死,而其他病变不足以解释猝死。结论 一切原发或继发性心脏神经病均可致猝死。     

IMMIGRATION POLICY,BORDER SECURITY,AND MIGRANT DEATHS: AN IMPACT EVALUATION OF LIFE‐SAVING EFFORTS UNDER THE BORDER SAFETY INITIATIVE*

Subsequent to U.S. Border Patrol (USBP) efforts to control illegal immigration throughout the 1990s, concern arose over an apparent increase in deaths of illegal migrants as they began to undertake more treacherous routes to enter the United States from Mexico. In response, the Border Safety Initiative (BSI) was created to increase safety along the southwest border. Using multiple data sources, including the USBP BSI Incident Tracking System, this study evaluated the impact of life‐saving efforts performed under the BSI program. Results indicate that there has been no overall reduction in the rate of migrant deaths since BSI has been in operation. However, an evaluation of BORSTAR search and rescue teams and the 2003 Lateral Repatriation Program (LRP), which returned apprehended migrants from Tucson sector to less hazardous places along the border, were found to be effective in preventing migrant deaths. Policy Implications: Critics of U.S. immigration policy claim that the only way reductions in migrant deaths along the U.S.‐Mexico border can be achieved is through liberalization of immigration policy and relaxing of border security. Yet, for more than a decade, U.S. policy makers have increased restrictions on immigration and have tightened security at the borders. Considering this, alternative means must be deployed in order to save migrant lives in the near term rather than waiting for a reversal of immigration policy. This study suggests that proactive life‐saving measures implemented through a harm‐reduction strategy can have some impact on saving migrant lives.     

论死刑不引渡原则

死刑不引渡原则是现代引渡制度的产物,是随着人权观念的兴起逐步形成和发展起来的。但在实践中,对于死刑的界定却存在着争议,并且请求国与被请求国也常常对是否需要判处死刑存在不同的看法,这些都会对死刑不引渡原则的适用产生影响。另外,死刑不引渡原则是否构成了国际习惯法也没有定论。由于我国现阶段不可能会完全废除死刑,所以在同废除了死刑的国家进行引渡合作时就有可能产生纠纷,为此,我国《引渡法》也应引入死刑不引渡原则。     

故意杀人罪的死刑裁量基准——“丁汉忠案”的文本梳理和法理审视

目前我国有关故意杀人罪中死刑裁量因素的审查难有真切、统一的基准,而在司法实践中对相关刑法条文含义的理解和阐释较为草率;最高人民法院的指导性案例体现的裁判趣旨未得到充分领会;各量刑因素的作用莫衷一是、标准不一,“估堆”量刑的困境萦绕其间,因而须探索故意杀人罪中相对合理的死刑裁量基准。具体而言,须区分各量刑因素的轻重、位阶,建构以责任刑为主、预防刑为辅的死刑裁量基准。至于是否入围死刑圈主要是仰仗责任刑阶段的判断。若责任刑阶段均是从严因素,基本会入围死刑圈的审查。死刑圈内的三种准刑种如何抉择,取决于对行为人的人身危险性判断。在预防刑阶段若均是从宽因素,一般死缓的判决即可满足要求;若从宽因素和从严因素交错,死缓限制减刑的判决基本可满足要求;若只有从严因素,则有判决死刑立即执行的可能。     

Death and Us

As Leon Kass has noted, the conquest of illness and death has long been “the unstated but implicit goal of modern medical science.” But it is unstated no more. Since the late 1990s, a new generation of scientists and enthusiasts has emerged to proclaim the feasibility and desirability of radical life extension. What they promise is not just longer life, better health, and heightened vitality, but a transformation of ourselves into the sort of beings we have long wished to be, but have repeatedly failed to become: beings who are completely fulfilled and living in perfect harmony with others. Despite the obvious and profound appeal of such a fantasy, attempts to realize it, even if successful scientifically, might prove to be disastrous culturally, for reasons that go beyond concerns about the alteration of existing social structures. Ultimately, as Freud argued, life might well become stagnant, “shallow and empty,” while the fear of death might become all the more crippling.

略论死刑复核中“发回”案件的重新审判

在重新审判＂发回＂死刑案件的司法实践中,对被告人容易存在有罪推定的倾向、依据补强证据再次适用死刑的倾向和漠视侦控行为合法性的倾向。为此重审法院应杜绝片面依据侦控机关提供的不利于被告人的存疑补强证据,对被告人再次适用死刑;对＂事实不清、证据不足＂发回的死刑案件,如果经过重审认定的案件事实没有发生重大变化,一般也不宜对被告人再次适用死刑。