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Evaluation of the Postmortem Glucose and Glycogen Levels in Hepatic,Renal, Muscle,and Brain Tissues: Is It Possible to Estimate Postmortem Interval Using These Parameters? 下载免费PDF全文
Alper Gümüş M.D. Burak Gümüş M.D. Erdal Özer M.D. Esma Yücetaş M.D. Uğur Yücetaş M.D. Emin Düz M.D. Soner Sarı M.D. Macit Koldaş M.D. 《Journal of forensic sciences》2016,61(Z1):S144-S149
The aim of our study was to investigate the postmortem levels of glucose and glycogen in hepatic, renal, muscle, and brain tissues and then examine the changes in those levels that could be useful for estimating postmortem interval. We established an animal model. Seventy female BALB/c albino mice were used in this study. After being sacrificed, the mice were randomly divided into six groups according to time elapsed since death (Group 1: 0 h; Group 2: 12 h; Group 3: 24 h; Group 4: 36 h; Group 5: 48 h; and Group 6: 60 h). Glucose levels were significantly different between groups for all tissues studied. Slope of the change per unit time was higher for the hepatic glucose levels. Based on these results, it is possible to estimate postmortem interval using postmortem glucose levels in hepatic tissue. Tissue‐specific assessment may contribute valuable information to postmortem interval studies. 相似文献
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Chong Zhou M.B.B.S. Andrea J. Yool Ph.D. Roger W. Byard M.D. 《Journal of forensic sciences》2017,62(4):921-925
Armanni–Ebstein lesions (AEL) occur in deaths related to uncontrolled diabetes mellitus. To investigate the relationship between AEL and terminal hyperglycemia, we retrospectively reviewed 71 cases with vitreous glucose levels ≥11.1 mmol/L; 27 (38%) cases had AEL (vitreous glucose 14.0–77.3 mmol/L); and 44 cases (62%) did not (vitreous glucose 11.1–91.9 mmol/L). There was no significant difference (p = 0.271) in vitreous glucose levels between the cases with AEL (mean 39.2, SD 16.7 mmol/L) and those without (mean 34.2, SD 19.8 mmol/L). Similarly, there was no difference in the degree of dehydration, renal failure, or osmolality. However, there was a significantly higher level of β‐hydroxybutyrate among the cases with AEL compared to those without (p = 0.007), suggesting that ketoacidosis may facilitate the development of AEL. Given the possible synergistic role of β‐hydroxybutyrate, the correlation between AEL and terminal hyperglycemia in animal studies may not be applicable to humans. AEL may also possibly occur with sublethal elevations in glucose. 相似文献
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